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Inhibition of enterovirus 71 infections and viral IRES activity by Fructus gardeniae and geniposide
- Source :
- European journal of medicinal chemistry. 62
- Publication Year :
- 2012
-
Abstract
- Fructus gardeniae has long been used by traditional Chinese medical practitioners for its anti-inflammatory, anti-oxidant, anti-tumor and anti-hyperlipidemic characteristics. Here we describe our finding that F. gardeniae greatly reduces anti-enterovirus 71 (EV71) activity, resulting in significant decreases in EV71 virus yields, EV71 infections, and internal ribosome entry site activity. We also found that geniposide, a primary F. gardeniae component, inhibited both EV71 replication and viral IRES activity. Our data suggest the presence of a mechanism that blocks viral protein translation. According to our findings, F. gardeniae and geniposide deserve a closer look as potential chemopreventive agents against EV71 infections.
- Subjects :
- Viral protein
Molecular Sequence Data
Microbial Sensitivity Tests
medicine.disease_cause
Virus Replication
Antiviral Agents
Virus
Chinese traditional
Cell Line, Tumor
Drug Discovery
Enterovirus 71
medicine
Enterovirus Infections
Humans
Iridoids
Medicine, Chinese Traditional
Pharmacology
biology
Organic Chemistry
RNA
Translation (biology)
General Medicine
biology.organism_classification
Gardenia
Virology
Enterovirus A, Human
Internal ribosome entry site
Cell culture
Protein Biosynthesis
RNA, Viral
Ribosomes
Drugs, Chinese Herbal
Subjects
Details
- ISSN :
- 17683254
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- European journal of medicinal chemistry
- Accession number :
- edsair.doi.dedup.....c9cbef11c7d0cf8b38b5fa49ca877a66