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Efficacy of Ibrexafungerp (SCY-078) against Candida auris in an In Vivo Guinea Pig Cutaneous Infection Model

Authors :
Mahmoud A. Ghannoum
David Angulo
N. Isham
Katyna Borroto-Esoda
Lisa Long
Stephen Barat
Source :
Antimicrob Agents Chemother
Publication Year :
2020
Publisher :
American Society for Microbiology, 2020.

Abstract

Candida auris has been shown to have a high risk of skin colonization in hospitalized patients, possibly contributing to nosocomial spread. In a guinea pig skin model, animals were evaluated for clinical appearance, tissue fungal burden, histology, and pharmacokinetics. Oral dosing with 10 mg/kg ibrexafungerp (IBX) reduced the severity of lesions and significantly reduced the C. auris fungal burden in infected animals compared with untreated controls.

Details

ISSN :
10986596 and 00664804
Volume :
64
Database :
OpenAIRE
Journal :
Antimicrobial Agents and Chemotherapy
Accession number :
edsair.doi.dedup.....c9d34164f4581caecc502d5a38238ec8
Full Text :
https://doi.org/10.1128/aac.00854-20