Hormone conditioned cancer chemotherapy for advanced breast cancer with special references to biological significance of adrenal gland

Although cancer chemotherapy or endocrine ablation therapy is effective by itself to some extent for advanced breast cancer, a synergistic effect would be expected if the both treatments were combined. It was demonstrated in the DMBA-induced rat mammary tumors that chemotherapy after oophorectomy was most effective to tumor regression with no mortality. Thus anticancer chemotherapy was suggested to be effective under suitable conditions caused by endocrine ablation therapy, and the “hormone conditioned cancer chemotherapy” for breast cancer was proposed.