Back to Search
Start Over
Indium-Catalyzed Intramolecular Hydroamidation of Alkynes: An Exo-Dig Cyclization for the Synthesis of Pyranoquinolines through Post-Transformational Reaction
- Source :
- Organic Letters. 19:6124-6127
- Publication Year :
- 2017
- Publisher :
- American Chemical Society (ACS), 2017.
-
Abstract
- An efficient approach for the synthesis of pyranoquinolines through the indium-catalyzed activation of alkynes is reported. Intramolecular hydroamidation of alkynes can proceed through alkyne activation by indium(III) and then 6-exo-dig cyclization, leading to a fused pyran ring with high selectivity, high atom economy, and good to excellent yields. The cyclization was accomplished through the oxygen, not the nitrogen, of the amide functional group.
- Subjects :
- inorganic chemicals
chemistry.chemical_classification
010405 organic chemistry
digestive, oral, and skin physiology
Organic Chemistry
Alkyne
010402 general chemistry
Ring (chemistry)
01 natural sciences
Biochemistry
Medicinal chemistry
0104 chemical sciences
Catalysis
chemistry.chemical_compound
chemistry
Pyran
Atom economy
Amide
Intramolecular force
Functional group
Organic chemistry
Physical and Theoretical Chemistry
Subjects
Details
- ISSN :
- 15237052 and 15237060
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Organic Letters
- Accession number :
- edsair.doi.dedup.....c9ef5b49cc8831cc32deee9604c148e4