Back to Search
Start Over
Immunohistochemical demonstration of the type III intermediate filament peripherin in human rectal mucosae and well-differentiated endocrine neoplasms
Immunohistochemical demonstration of the type III intermediate filament peripherin in human rectal mucosae and well-differentiated endocrine neoplasms
- Source :
- Europe PubMed Central, Scopus-Elsevier
- Publication Year :
- 2007
-
Abstract
- Peripherin is a type III neuronal intermediate filament and its expression is involved in the growth and development of the peripheral nervous systems. Peripherin expression has been reported in cutaneous endocrine carcinomas, but not in rectal well-differentiated endocrine neoplasms (carcinoid tumors). Well-differentiated endocrine neoplasms have been reported to have a relatively high incidence of metastasis, but there is no complete parameter for prediction of their malignant behavior. The aim of the present study was to clarify the expression of peripherin in human fetal and adult rectal mucosae and rectal well-differentiated endocrine neoplasms and the significance of peripherin expression in well-differentiated endocrine neoplasms. Expression of peripherin was studied immunohistochemically in 3 fetal hindgut mucosae, 10 non-neoplastic rectal mucosae, 12 rectal well-differentiated endocrine neoplasms without metastases, and 5 well-differentiated endocrine neoplasms with metastases. Adult rectal mucosal epithelial cells did not have peripherin. However, transient expression of peripherin was detected in the subgroup of epithelial cells of the fetal rectum. Peripherin was demonstrated in all of the rectal well-differentiated endocrine neoplasms without metastases (12/12 cases), but was absent from some of the well-differentiated endocrine neoplasms with metastases (3/5 cases). Constant expression of peripherin in rectal well-differentiated endocrine neoplasms without metastases (12/12) seems to reflect the phenotype of the subpopulation of epithelial cells confined to the fetal rectum. However, loss of its expression was observed in cases with metastases (3/5) and can be regarded as an additional parameter to predict the risk of metastasis in rectal well-differentiated endocrine neoplasms.
- Subjects :
- Adult
Male
Cancer Research
Pathology
medicine.medical_specialty
Carcinoid tumors
Peripherins
Rectum
Nerve Tissue Proteins
Biology
Metastasis
Intermediate Filament Proteins
medicine
Endocrine system
Humans
Intestinal Mucosa
Neoplasm Metastasis
Aged
Neoplasm Staging
Aged, 80 and over
Membrane Glycoproteins
Rectal Neoplasms
Cancer
Peripherin
General Medicine
Middle Aged
medicine.disease
Immunohistochemistry
stomatognathic diseases
medicine.anatomical_structure
Oncology
Endocrine neoplasm
Female
sense organs
Endocrine gland
Subjects
Details
- ISSN :
- 1021335X
- Volume :
- 18
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Oncology reports
- Accession number :
- edsair.doi.dedup.....c9f293ef6d39bcbb464d89096d1e7f3a