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Anti-chemokine antibodies after SARS-CoV-2 infection correlate with favorable disease course
- Source :
- bioRxiv
- Publication Year :
- 2022
-
Abstract
- Infection by SARS-CoV-2 leads to diverse symptoms, which can persist for months. While antiviral antibodies are protective, those targeting interferons and other immune factors are associated with adverse COVID-19 outcomes. Instead, we discovered that antibodies against specific chemokines are omnipresent after COVID-19, associated with favorable disease, and predictive of lack of long COVID symptoms at one year post infection. Anti-chemokine antibodies are present also in HIV-1 infection and autoimmune disorders, but they target different chemokines than those in COVID-19. Monoclonal antibodies derived from COVID- 19 convalescents that bind to the chemokine N-loop impair cell migration. Given the role of chemokines in orchestrating immune cell trafficking, naturally arising anti-chemokine antibodies associated with favorable COVID-19 may be beneficial by modulating the inflammatory response and thus bear therapeutic potential.One-Sentence Summary:Naturally arising anti-chemokine antibodies associate with favorable COVID-19 and predict lack of long COVID.
- Subjects :
- Article
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- bioRxiv : the preprint server for biology
- Accession number :
- edsair.doi.dedup.....ca04d395480f1e2dd56c6ba09c24dc0b