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Macrophage CCL22 expression in the tumor microenvironment and implications for survival in patients with squamous cell carcinoma of the tongue
- Source :
- Journal of oral pathologymedicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral PathologyREFERENCES. 48(8)
- Publication Year :
- 2019
-
Abstract
- BACKGROUND CCL22, mainly synthesized by monocyte-derived alternative (M2) macrophages, belongs to the CC family of chemokines. CCR4, the receptor for CCL22, is expressed in regulatory T cells (Tregs) and Th2 cells. The Yamamoto-Kohama (YK) mode of invasion has been associated with tumor prognosis. Herein, we investigated the role of CCL22 in the tumor microenvironment and its effect on the overall survival rate in patients with tongue squamous cell carcinoma (SCC). METHODS Tumor sections obtained from 92 patients with tongue SCC were graded based on the mode of invasion according to the YK classification. The expressions of several markers (CCL22, CD8, and Ki-67 by immunohistochemistry; CCR4 and FoxP3 by immunofluorescent staining) were evaluated. Student's t test and chi-square tests were used to compare differences between numerical variables and groups, respectively. Survival curves were plotted according to the Kaplan-Meier method and compared using a log-rank test. Hazard ratios and 95% confidence intervals were estimated using univariate or multivariate Cox proportional hazard models. RESULTS The expression of CCL22 was significantly correlated with YK classification, overall survival rate (P
- Subjects :
- Adult
Male
Cancer Research
CCR4
Tumor-associated macrophage
T-Lymphocytes, Regulatory
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Tumor Microenvironment
Medicine
Humans
Survival analysis
Aged
Proportional Hazards Models
Aged, 80 and over
Chemokine CCL22
Tumor microenvironment
business.industry
Macrophages
Hazard ratio
FOXP3
030206 dentistry
Middle Aged
Tongue Neoplasms
Survival Rate
Otorhinolaryngology
030220 oncology & carcinogenesis
Cancer research
Carcinoma, Squamous Cell
Periodontics
Immunohistochemistry
Female
Oral Surgery
business
CD8
Subjects
Details
- ISSN :
- 16000714
- Volume :
- 48
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of oral pathologymedicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral PathologyREFERENCES
- Accession number :
- edsair.doi.dedup.....ca3f1d91a145309f05379ff5295ec6cb