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Multimodality therapy for small cell carcinoma of the lung —The role of surgical treatment
Multimodality therapy for small cell carcinoma of the lung —The role of surgical treatment
- Source :
- The Japanese Journal of Surgery. 19:699-707
- Publication Year :
- 1989
- Publisher :
- Springer Science and Business Media LLC, 1989.
-
Abstract
- Reviewing the outcome of 70 cases of clinically localized small cell lung cancer (SCLC) treated with combined modality treatment, we attempted to define the role of resection in this disease. The survival rate for all cases was 37 per cent at 2 years and 23 per cent at 3 years with a median survival time (MST) of 14 months. For 25 resected cases the overall 5-year survival rate was 37 per cent with an MST of 26 months. According to clinical staging, 5-year survival was 64 per cent for stage I and 20 per cent for stage II. However, none of the stage III cases achieved long-term survival, of over 3 years. In 45 non-resected cases, the overall response rate was 84 per cent with a 44 per cent complete response. The overall survival rate was 27 per cent at 2 years and 14 per cent at 3 years with an MST of 11 months. The 20 cases who achieved complete response had an MST of 26 months with 51 per cent alive at 2 years and 19 per cent at 5 years. Thus, we consider that lung resection is definitely indicated in cases with stage I and probably stage II SCLC. For stage III, however, particularly in cases with N2 disease, resection seems to offer no special benefit in favor of survival compared to combination chemotherapy and radiotherapy.
- Subjects :
- Adult
Male
medicine.medical_specialty
Lung Neoplasms
medicine.medical_treatment
Small-cell carcinoma
medicine
Carcinoma
Humans
Carcinoma, Small Cell
Stage (cooking)
Survival rate
Aged
Aged, 80 and over
Chemotherapy
business.industry
Respiratory disease
Combination chemotherapy
General Medicine
Middle Aged
Prognosis
medicine.disease
Combined Modality Therapy
Surgery
Radiation therapy
Evaluation Studies as Topic
Female
business
Subjects
Details
- ISSN :
- 14362813 and 00471909
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- The Japanese Journal of Surgery
- Accession number :
- edsair.doi.dedup.....ca3f4d5f95511c19c1470f97d0111216
- Full Text :
- https://doi.org/10.1007/bf02471721