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Multimodality therapy for small cell carcinoma of the lung —The role of surgical treatment

Multimodality therapy for small cell carcinoma of the lung —The role of surgical treatment

Authors :
Kazuo Hata
Akira Motohiro
Tomoharu kuda
Hiroshi Aso
Mitsuo Ohta
Nobuyuki Hara
Yukito Ichinose
Source :
The Japanese Journal of Surgery. 19:699-707
Publication Year :
1989
Publisher :
Springer Science and Business Media LLC, 1989.

Abstract

Reviewing the outcome of 70 cases of clinically localized small cell lung cancer (SCLC) treated with combined modality treatment, we attempted to define the role of resection in this disease. The survival rate for all cases was 37 per cent at 2 years and 23 per cent at 3 years with a median survival time (MST) of 14 months. For 25 resected cases the overall 5-year survival rate was 37 per cent with an MST of 26 months. According to clinical staging, 5-year survival was 64 per cent for stage I and 20 per cent for stage II. However, none of the stage III cases achieved long-term survival, of over 3 years. In 45 non-resected cases, the overall response rate was 84 per cent with a 44 per cent complete response. The overall survival rate was 27 per cent at 2 years and 14 per cent at 3 years with an MST of 11 months. The 20 cases who achieved complete response had an MST of 26 months with 51 per cent alive at 2 years and 19 per cent at 5 years. Thus, we consider that lung resection is definitely indicated in cases with stage I and probably stage II SCLC. For stage III, however, particularly in cases with N2 disease, resection seems to offer no special benefit in favor of survival compared to combination chemotherapy and radiotherapy.

Details

ISSN :
14362813 and 00471909
Volume :
19
Database :
OpenAIRE
Journal :
The Japanese Journal of Surgery
Accession number :
edsair.doi.dedup.....ca3f4d5f95511c19c1470f97d0111216
Full Text :
https://doi.org/10.1007/bf02471721