Design considerations for point-of-need devices based on nucleic acid amplification for COVID-19 diagnostics and beyond

Currently, the ongoing pandemic has created an unprecedented pressure for the development of various analytical assays and especially their immediate practical applications. A number of tests based on different principles such as immunoassay [1], electrochemistry [2], nucleic acid amplification tests (NAATs) [3] and others have been reported [4]. Immunoassays and NAATs are currently being utilized clinically, while systems based on several other principles did not go further than the acceptance of manuscripts for publication.