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Spontaneous Activity Drives Local Synaptic Plasticity In Vivo
- Source :
- Neuron, 87(2), 399-410. Cell Press
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- SummarySpontaneous activity fine-tunes neuronal connections in the developing brain. To explore the underlying synaptic plasticity mechanisms, we monitored naturally occurring changes in spontaneous activity at individual synapses with whole-cell patch-clamp recordings and simultaneous calcium imaging in the mouse visual cortex in vivo. Analyzing activity changes across large populations of synapses revealed a simple and efficient local plasticity rule: synapses that exhibit low synchronicity with nearby neighbors (
- Subjects :
- Patch-Clamp Techniques
Nerve net
Neuroscience(all)
Action Potentials
Mice, Transgenic
Hippocampal formation
Neurotransmission
Biology
In Vitro Techniques
Models, Biological
03 medical and health sciences
Mice
0302 clinical medicine
Calcium imaging
Organ Culture Techniques
Quinoxalines
Neuroplasticity
Metaplasticity
medicine
Animals
Computer Simulation
030304 developmental biology
Visual Cortex
Neurons
0303 health sciences
Neuronal Plasticity
General Neuroscience
Electric Stimulation
Mice, Inbred C57BL
Luminescent Proteins
Synaptic fatigue
medicine.anatomical_structure
Animals, Newborn
Synaptic plasticity
Calcium
Nerve Net
Neuroscience
Excitatory Amino Acid Antagonists
030217 neurology & neurosurgery
Signal Transduction
Subjects
Details
- ISSN :
- 08966273
- Volume :
- 87
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Neuron
- Accession number :
- edsair.doi.dedup.....ca4b714f2081619b38349b23eb60fd2c
- Full Text :
- https://doi.org/10.1016/j.neuron.2015.06.029