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Design and Synthesis of Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter Targeting Potential Agents for Alzheimer's Disease
- Source :
- Organic Letters. 4:3359-3362
- Publication Year :
- 2002
- Publisher :
- American Chemical Society (ACS), 2002.
-
Abstract
- Highly efficient acetylcholinesterase (AChE) and serotonin transporter (SERT) dual inhibitors, (S)-4 and (R)-13 were designed and synthesized on the basis of the hypothetical model of AChE active site. Both compounds showed potent inhibitory activities against AChE and SERT. [structure: see text]
- Subjects :
- Serotonin
Aché
Pharmacology
Inhibitory postsynaptic potential
Biochemistry
Inhibitory Concentration 50
chemistry.chemical_compound
Alzheimer Disease
Humans
Inhibitory concentration 50
Physical and Theoretical Chemistry
Binding site
Serotonin transporter
Binding Sites
Molecular Structure
biology
Organic Chemistry
Active site
Serotonin metabolism
Acetylcholinesterase
language.human_language
chemistry
Drug Design
biology.protein
language
Cholinesterase Inhibitors
Selective Serotonin Reuptake Inhibitors
Subjects
Details
- ISSN :
- 15237052 and 15237060
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Organic Letters
- Accession number :
- edsair.doi.dedup.....ca4c2e8f40e10b02aad45efb1c3a91db
- Full Text :
- https://doi.org/10.1021/ol026418e