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Multiple functions of USP18
- Source :
- Cell Death & Disease
- Publication Year :
- 2016
-
Abstract
- Since the discovery of the ubiquitin system and the description of its important role in the degradation of proteins, many studies have shown the importance of ubiquitin-specific peptidases (USPs). One special member of this family is the USP18 protein (formerly UBP43). In the past two decades, several functions of USP18 have been discovered: this protein is not only an isopeptidase but also a potent inhibitor of interferon signaling. Therefore, USP18 functions as 'a' maestro of many biological pathways in various cell types. This review outlines multiple functions of USP18 in the regulation of various immunological processes, including pathogen control, cancer development, and autoimmune diseases. OA gold
- Subjects :
- 0301 basic medicine
Cancer Research
Isopeptidase
Cell type
Carcinogenesis
Immunology
Medizin
Review
Computational biology
medicine.disease_cause
Models, Biological
Autoimmune Diseases
Biological pathway
03 medical and health sciences
Cellular and Molecular Neuroscience
Ubiquitin
Interferon
Endopeptidases
medicine
Animals
Humans
Pathogen
biology
Cell Biology
Anti-Bacterial Agents
030104 developmental biology
Virus Diseases
biology.protein
Cancer development
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Cell Death & Disease
- Accession number :
- edsair.doi.dedup.....ca5ee1d985fe4d3f295ca50f250ad483