Study on the correlation between urinary retinol-binding protein and nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) affects human health worldwide. Our objective was to explore the correlation between urinary retinol-binding protein (URBP) and NAFLD.This cross-sectional study included 445 NAFLD patients and 911 healthy controls. The URBP level and other parameters were measured.The URBP level (expressed by the RBP/creatinine ratio) was higher in the NAFLD patients compared with the non-NAFLD patients. The urinary RBP/creatinine ratio was an independent risk factor for NAFLD after univariate and multivariate regression analysis, with the or values of 2.271 (1.795-2.872, P0.001) and 2.338 (1.775-3.080, P0.001), respectively. The prevalence of the urinary RBP/creatinine ratio (groups 1, 2, 3, 4) was 20.0%, 17.3%, 27.3%, and 35.4%, respectively (P0.001), and the prevalence of NAFLD in the high urinary RBP/creatinine ratio group was significantly higher than that in the low urinary RBP/creatinine ratio group.Our results revealed that the urinary RBP/creatinine ratio was an independent risk factor for NAFLD.Nealkoholna masna jetra (NAFLD) ima negativan uticaj na zdravlje ljudi širom sveta. Naš rad je bio usmeren na istraživanje povezanosti između urinarnog retinol-vezujućeg proteina (URBP) i nealkoholne masne jetre.Istraživanje, sprovedeno kao studija preseka (cross-sectional study), obuhvatilo je 445 pacijenata sa dijagnozom nealkoholne masne jetre i 911 zdravih osoba u kontrolnoj grupi. U istraživanju su mereni nivo urinarnog retinol-vezujućeg proteina (URBP) kao i drugi parametri.Nivo urinarnog retinol-vezujućeg proteina (koji se izražava kao odnos retinol-vezujućeg proteina i kreatinina) bio je viši kod pacijenata sa dijagnozom nealkoholne masne jetre nego kod onih bez ove dijagnoze. Odnos urinarnog retinol-vezujućeg proteina i kreatinina pokazao se kao nezavisan faktor rizika za nealkoholnu masnu jetru, nakon regresionih analiza sa jednom i više varijabli, sa dobijenim vrednostima koeficijenta korelacije (OR) koje redom iznose - 2,271 (1,795-2.872, P0,001) i 2,338 (1,775-3,080, P0,001). Učestalost odnosa urinarnog retinol-vezujućeg proteina i kreatinina (u grupama 1, 2, 3 i 4) bila je, redom, 20,0%, 17,3%, 27,3% i 35,4% (P0,001), a učestalost nealkoholne masne jetre u grupi sa visokim od no som bila je znatno veća nego u grupi sa niskim odnosom.Rezultati istraživanja otkrili su da je odnos urinarnog retinol-vezujućeg proteina i kreatinina nezavisan faktor rizika za nealkoholnu masnu jetru.