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A Systematic Review of Recently Reported Marine Derived Natural Product Kinase Inhibitors
- Source :
- Marine Drugs, Marine Drugs, Vol 17, Iss 9, p 493 (2019)
- Publication Year :
- 2019
- Publisher :
- MDPI, 2019.
-
Abstract
- Protein kinases are validated drug targets for a number of therapeutic areas, as kinase deregulation is known to play an essential role in many disease states. Many investigated protein kinase inhibitors are natural product small molecules or their derivatives. Many marine-derived natural products from various marine sources, such as bacteria and cyanobacteria, fungi, animals, algae, soft corals, sponges, etc. have been found to have potent kinase inhibitory activity, or desirable pharmacophores for further development. This review covers the new compounds reported from the beginning of 2014 through the middle of 2019 as having been isolated from marine organisms and having potential therapeutic applications due to kinase inhibitory and associated bioactivities. Moreover, some existing clinical drugs based on marine-derived natural product scaffolds are also discussed.
- Subjects :
- Drug
Cyanobacteria
Aquatic Organisms
media_common.quotation_subject
Drug Evaluation, Preclinical
Pharmaceutical Science
Review
chemistry.chemical_compound
Neoplasms
Drug Discovery
kinase inhibitors
Animals
Humans
Protein kinase A
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
lcsh:QH301-705.5
Protein Kinase Inhibitors
media_common
Biological Products
Clinical Trials as Topic
Natural product
biology
Molecular Structure
Kinase
marine natural products
Bacterial Infections
biology.organism_classification
Small molecule
drug development
Biochemistry
chemistry
Drug development
lcsh:Biology (General)
Drug Design
Pharmacophore
Subjects
Details
- Language :
- English
- ISSN :
- 16603397
- Volume :
- 17
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Marine Drugs
- Accession number :
- edsair.doi.dedup.....ca7f34cdb2d62ae50530b51295891c4a