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Differentiation of COVID-19 signs and symptoms from allergic rhinitis and common cold: An ARIA-EAACI-GA

Authors :
Jere Reijula
De Yun Wang
Ralph Mösges
Tomohisa Iinuma
Jean Luc Fauquert
Nelson Rosario
Yehia El-Gamal
René Maximiliano Gómez
Tari Haahtela
Vincenzo Patella
Lorenzo Cecchi
Petr Panzner
Yoshitaka Okamoto
Oliver Pfaar
Luis Caraballo
Paulo Augusto Moreira Camargos
Filip Raciborski
Florin Mihaltan
Ken Ohta
Brian J. Lipworth
Kimi Okubo
Juan Carlos Ivancevich
Fulvio Braido
Ioana Agache
Frederico S. Regateiro
Neven Miculinic
Tuula Vasankari
R. Emuzyte
Arunas Valiulis
Yousser Mohammad
Torsten Zuberbier
Osman M. Yusuf
Ewa Jassem
Cezmi A. Akdis
Jean Bousquet
Alessandro Fiocchi
Jan Hagemann
Claus Bachert
Davor Plavec
K. S. Bennoor
Marek Jutel
Désirée Larenas-Linnemann
Stephen Montefort
Stefano Del Giacco
Przemyslaw Kardas
Erkka Valovirta
Mark S. Dykewicz
Antonio Valero
Wienczyslawa Czarlewski
Thomas B. Casale
Gabrielle L. Onorato
Omer Kalayci
Ludger Klimek
Joaquin Sastre
João Fonseca
Siân Williams
Karl Christian Bergmann
Marek Niedoszytko
Bilun Gemicioglu
Mario E. Zernotti
Musa Khaitov
H. Neffen
Robert M. Naclerio
Joaquim Mullol
Ana Pereira
Piotr Kuna
Michael Makris
Maria Teresa Ventura
Ioanna Tsiligianni
Dirceu Solé
Arzu Yorgancioglu
Charlotte Suppli-Ulrik
M. Gotua
Emmanuel P. Prokopakis
Dana Wallace
Jorge Maspero
Wytske Fokkens
Eckard Hamelmann
Antonino Romano
Dejan Dokic
Todor A. Popov
Violeta Kvedariene
Derek K. Chu
Anna Bedbrook
Dermot Ryan
Motohiro Ebisawa
Tomas Chivato
Giovanni Passalacqua
Menachem Rottem
Mário Morais-Almeida
Victoria Cardona
Bolesław Samoliński
Cristiana Stellato
Nikolaos G. Papadopoulos
Milan Sova
Jaime Correia-de-Sousa
Sietze Reitsma
Cemal Cingi
Francesca Puggioni
Robyn E O'Hehir
HUS Inflammation Center
Department of Dermatology, Allergology and Venereology
HUS Internal Medicine and Rehabilitation
Department of Public Health
Clinicum
Keuhkosairauksien yksikkö
Helsinki University Hospital Area
University of Helsinki
University Medical Center of the Johannes Gutenberg-University Mainz
Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR)
Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA)
Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)
University of Wrocław [Poland] (UWr)
Swiss Institute of Allergy and Asthma Research (SIAF)
Universität Zürich [Zürich] = University of Zurich (UZH)
Transilvania University of Brasov
Humboldt University Of Berlin
Medical Consulting Czarlewski
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES)
MASK-air
Ghent University Hospital
Sun Yat-Sen University [Guangzhou] (SYSU)
Karolinska Institutet [Stockholm]
National Institute of Diseases of the Chest and Hospital (NIDCH)
Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
Ospedale Policlinico San Martino [Genoa]
Universidade Federal de Minas Gerais = Federal University of Minas Gerais [Belo Horizonte, Brazil] (UFMG)
University of Cartagena
Foundation for the Development of Medical and Biological Sciences (FUNDEMEB)
Vall d'Hebron University Hospital [Barcelona]
Allergy Unit [Malaga, Spain] (National Network ARADyAL)
Hospital Regional Universitario de Málaga = Regional University Hospital of Malaga [Spain]
University of South Florida [Tampa] (USF)
Azienda Usl Toscana centro [Firenze]
CEU-San Pablo University and HM-Hospitals School of Medicine
McMaster University [Hamilton, Ontario]
Eskisehir Osmangazi University
Universidade do Minho = University of Minho [Braga]
Life and Health Sciences Research Institute [Braga] (ICVS)
University of Minho [Braga]
The International Primary Care Respiratory Group (IPCRG)
Università degli Studi di Cagliari = University of Cagliari (UniCa)
Sts. Cyril and Methodius University
Saint Louis University School of Medicine [St Louis]
Sagamihara National Hospital [Kanagawa, Japan]
Ain Shams University (ASU)
Vilnius University [Vilnius]
Service de Pédiatrie Générale [CHU Clermont-Ferrand]
CHU Estaing [Clermont-Ferrand]
CHU Clermont-Ferrand-CHU Clermont-Ferrand
Bambino Gesù Children’s Hospital [Rome, Italy]
Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC)
University of Amsterdam [Amsterdam] (UvA)
European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA)
Center of Research in Health Technologies and Information Systems (CINTESIS)
Universidade do Porto = University of Porto
CUF Porto Hospital
Cerrahpasa Faculty of Medicine
Istanbul University
ALAS Medical Institute
Center for Allergy and Immunology Research [Tbilisi]
Helsingin yliopisto = Helsingfors universitet = University of Helsinki
Universität Bielefeld = Bielefeld University
Chiba University Hospital
Servicio de Alergia e ImmunologiaBuenos Aires (Clinica Santa Isabel)
Medical University of Gdańsk
Faculty of Medicine [Hacettepe University]
Hacettepe University = Hacettepe Üniversitesi
Medical University of Łódź (MUL)
Federal Medicobiological Agency [Moscow, Russian Federation]
Hospital Medica Sur [Mexico City, Mexico]
Ninewells Hospital and Medical School [Dundee]
University General Hospital ' Attikon ' [Athens, Greece]
Argentine Association of Allergy and Immunology
Marius Nasta Institute of Pneumology
Tishreen University
Université de Damas = Damascus University
University of Malta [Malta]
Hospital CUF Descobertas
Clinical Research International Ltd [Hamburg, Germany] (CRI)
Johns Hopkins University School of Medicine [Baltimore]
Nemours/Alfred I. du Pont Hospital for Children
Monash University [Melbourne]
Tokyo National Hospital
Nippon Medical School [Tokyo, Japon]
Medicine Charles University and General Faculty Hospital in Prague
Royal Manchester Children's Hospital
University of Manchester [Manchester]
Università degli studi di Genova = University of Genoa (UniGe)
'Santa Maria della Speranza' Hospital
Philipps Universität Marburg = Philipps University of Marburg
J.J. Strossmayer University of Osijek
Children’s Hospital Srebrnjak [Zagreb, Croatia]
St. Ivan Rilski University Hospital
University of Crete [Heraklion] (UOC)
IRCCS Humanitas [Rozzano, Italy]
Medical University of Warsaw - Poland
Centro Hospitalar e Universitário [Coimbra]
Amsterdam UMC - Amsterdam University Medical Center
Istituto di Ricovero e Cura a Carattere Scientifico [Troina, Italy] (IRCCS)
Oasi Maria Santissima Srl [Troina, Italy]
Clinica G.B. Morgagni (Fondazione Mediterranea)
Pontifical Catholic University of Paraná (PUCPR)
Pontifícia Universidade Católica do Paraná (PUCPR)
Ha’Emek Medical Center [Afula, Israel]
Pediatric Endocrine Institute [Afula, Israel]
Usher Institute of Population Health Sciences and Informatics [Edinburgh, U.K.]
University of Edinburgh
Federal University of Sao Paulo (Unifesp)
University Hospital Olomouc [Czech Republic]
University of Salerno (UNISA)
Copenhagen University Hospital
Universitat de Barcelona (UB)
European Academy of Paediatrics (EAP/UEMS-SP)
University of Turku
Suomen Terveystalo Allergy Clinic
Finnish Lung Health Association
Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA)
Nova Southeastern University (NSU)
Yong Loo Lin School of Medicine [Singapore]
Department of Biology, Faculty of Sciences & Liberal Arts, Celal Bayar University
Manisa Celal Bayar University
The Allergy & Asthma Institute, Pakistan (IPCRG)
Universidad Nacional de Villa María
Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
Allergiezentrum Wiesbaden
Salvy-Córdoba, Nathalie
Ear, Nose and Throat
AII - Inflammatory diseases
Source :
Allergy, Allergy, 2021, 76 (8), pp.2354-2366. ⟨10.1111/all.14815⟩, Hagemann, J, Onorato, G L, Jutel, M, Akdis, C A, Agache, I, Zuberbier, T, Czarlewski, W, Mullol, J, Bedbrook, A, Bachert, C, Bennoor, K S, Bergmann, K C, Braido, F, Camargos, P, Caraballo, L, Cardona, V, Casale, T, Cecchi, L, Chivato, T, Chu, D K, Cingi, C, Correia-de-Sousa, J, del Giacco, S, Dokic, D, Dykewicz, M, Ebisawa, M, El-Gamal✝, Y, Emuzyte, R, Fauquert, J L, Fiocchi, A, Fokkens, W J, Fonseca, J A, Gemicioglu, B, Gomez, R M, Gotua, M, Haahtela, T, Hamelmann, E, Iinuma, T, Ivancevich, J C, Jassem, E, Kalayci, O, Kardas, P, Khaitov, M, Kuna, P, Kvedariene, V, Larenas-Linnemann, D E, Lipworth, B, Makris, M, Maspero, J F, Miculinic, N, Mihaltan, F, Mohammad, Y, Montefort, S, Morais-Almeida, M, Mösges, R, Naclerio, R, Neffen, H, Niedoszytko, M, O’Hehir, R E, Ohta, K, Okamoto, Y, Okubo, K, Panzner, P, Papadopoulos, N G, Passalacqua, G, Patella, V, Pereira, A, Pfaar, O, Plavec, D, Popov, T A, Prokopakis, E P, Puggioni, F, Raciborski, F, Reijula, J, Regateiro, F S, Reitsma, S, Romano, A, Rosario, N, Rottem, M, Ryan, D, Samolinski, B, Sastre, J, Solé, D, Sova, M, Stellato, C, Suppli-Ulrik, C, Tsiligianni, I, Valero, A, Valiulis, A, Valovirta, E, Vasankari, T, Ventura, M T, Wallace, D, Wang, D Y, Williams, S, Yorgancioglu, A, Yusuf, O M, Zernotti, M, Bousquet, J & Klimek, L 2021, ' Differentiation of COVID-19 signs and symptoms from allergic rhinitis and common cold : An ARIA-EAACI-GA 2 LEN consensus ', Allergy: European Journal of Allergy and Clinical Immunology, vol. 76, no. 8, pp. 2354-2366 . https://doi.org/10.1111/all.14815, Allergy: European Journal of Allergy and Clinical Immunology, 76(8), 2354-2366. Wiley-Blackwell
Publication Year :
2021

Abstract

Background Although there are many asymptomatic patients, one of the problems of COVID-19 is early recognition of the disease. COVID-19 symptoms are polymorphic and may include upper respiratory symptoms. However, COVID-19 symptoms may be mistaken with the common cold or allergic rhinitis. An ARIA-EAACI study group attempted to differentiate upper respiratory symptoms between the three diseases. Methods A modified Delphi process was used. The ARIA members who were seeing COVID-19 patients were asked to fill in a questionnaire on the upper airway symptoms of COVID-19, common cold and allergic rhinitis. Results Among the 192 ARIA members who were invited to respond to the questionnaire, 89 responded and 87 questionnaires were analysed. The consensus was then reported. A two-way ANOVA revealed significant differences in the symptom intensity between the three diseases (p < .001). Conclusions This modified Delphi approach enabled the differentiation of upper respiratory symptoms between COVID-19, the common cold and allergic rhinitis. An electronic algorithm will be devised using the questionnaire.

Details

ISSN :
13989995 and 01054538
Volume :
76
Issue :
8
Database :
OpenAIRE
Journal :
Allergy
Accession number :
edsair.doi.dedup.....ca86d74c10d8261865c72c0b21fe5500