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Subcutaneously Injectable Hyaluronic Acid Hydrogel for Sustained Release of Donepezil with Reduced Initial Burst Release: Effect of Hybridization of Microstructured Lipid Carriers and Albumin

Authors :
Sungho Kim
So-Yeon Yoon
Nae-Won Kang
Ju-Hwan Park
Hyun-Jong Cho
Dae-Duk Kim
Jae Young Lee
Na-Young Yu
Source :
Pharmaceutics, Volume 13, Issue 6, Pharmaceutics, Vol 13, Iss 864, p 864 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

The daily oral administration of acetylcholinesterase (AChE) inhibitors for Alzheimer’s disease features low patient compliance and can lead to low efficacy or high toxicity owing to irregular intake. Herein, we developed a subcutaneously injectable hyaluronic acid hydrogel (MLC/HSA hydrogel) hybridized with microstructured lipid carriers (MLCs) and human serum albumin (HSA) for the sustained release of donepezil (DNP) with reduced initial burst release. The lipid carrier was designed to have a microsized mean diameter (32.6 ± 12.8 µm) to be well-localized in the hydrogel. The hybridization of MLCs and HSA enhanced the structural integrity of the HA hydrogel, as demonstrated by the measurements of storage modulus (G′), loss modulus (G″), and viscosity. In the pharmacokinetic study, subcutaneous administration of MLC/HSA hydrogel in rats prolonged the release of DNP for up to seven days and reduced the initial plasma concentration, where the Cmax value was 0.3-fold lower than that of the control hydrogel without a significant change in the AUClast value. Histological analyses of the hydrogels supported their biocompatibility for subcutaneous injection. These results suggest that a new hybrid MLC/HSA hydrogel could be promising as a subcutaneously injectable controlled drug delivery system for the treatment of Alzheimer’s disease.

Details

ISSN :
19994923
Volume :
13
Database :
OpenAIRE
Journal :
Pharmaceutics
Accession number :
edsair.doi.dedup.....ca8cbf3610c18b9a300ccaf4cc782f18