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Jakyakgamcho-tang in the relief of delayed-onset muscle soreness in healthy adults: study protocol for a randomized, double-blind, placebo-controlled, crossover design clinical trial
- Source :
- Trials, Vol 21, Iss 1, Pp 1-10 (2020), Trials
- Publication Year :
- 2020
- Publisher :
- BMC, 2020.
-
Abstract
- Background Muscle soreness after exercise, called delayed-onset muscle soreness (DOMS), may cause significant changes in muscle function and may increase the risk of sports injuries. Therefore, various therapeutic strategies have been studied to help recovery after exercise. Jakyakgamcho-tang (JGT) is a widely prescribed herbal medicine to treat muscle pain and cramps in traditional Eastern medicine. The aim of this study is to evaluate the effect of JGT for reducing pain and improving muscle damage after exercise. Methods This study is a randomized, double-blind, placebo-controlled, crossover design clinical trial. A total of 30 healthy male adults will be recruited. Subjects who voluntarily wish to participate in this study will be hospitalized for 4 days. On the first day, the subjects will perform a standardized treadmill exercise for 1 h to induce DOMS. After the exercise, the subjects will take either JGT or a placebo for 3 days. After a more than 1 week wash-out period, the subjects will repeat the same process with the other drug. Pain intensity, calf circumference, and pain threshold will be measured as outcome measures. Blood tests and blood pressure will be measured as safety assessments. In addition, blood tests for muscle damage and inflammation markers, such as creatine kinase, interleukin-6, and C-reactive protein, will be analyzed. Discussion This will be the first trial to assess the effect of JGT on exercise-induced muscle soreness. Our findings will provide valuable data to determine the clinical effects of JGT on DOMS. Trial registration Clinical Research Information Sevice, KCT0003457. Registered on 29 January 2019.
- Subjects :
- Adult
Pain Threshold
medicine.medical_specialty
Shaoyaogancao-tang
Medicine (miscellaneous)
Placebo
Study Protocol
03 medical and health sciences
0302 clinical medicine
Double-Blind Method
Shakuyakukanzoto
Delayed onset muscle soreness
Threshold of pain
medicine
Humans
Pharmacology (medical)
Muscle, Skeletal
Creatine Kinase
Exercise
Pain Measurement
Randomized Controlled Trials as Topic
lcsh:R5-920
Cross-Over Studies
biology
business.industry
Myalgia
Jakyakgamcho-tang
Crossover study
Clinical trial
Peony licorice decoction
Clinical research
Blood pressure
Exercise Test
biology.protein
Physical therapy
030211 gastroenterology & hepatology
Creatine kinase
Delayed-onset muscle soreness
medicine.symptom
Herbal medicine
business
lcsh:Medicine (General)
030217 neurology & neurosurgery
Drugs, Chinese Herbal
Subjects
Details
- Language :
- English
- ISSN :
- 17456215
- Volume :
- 21
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Trials
- Accession number :
- edsair.doi.dedup.....ca9fdfa93eecd1167faed9479e5f2988