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Acromegaly treatment in Romania. How close are we to disease control?
- Source :
- Endokrynologia Polska.
- Publication Year :
- 2015
- Publisher :
- VM Media SP. zo.o VM Group SK, 2015.
-
Abstract
- Introduction: In Romania, no nationwide data for acromegaly treatment and control rate are available. Our objective was to assess the acromegaly control rate in a tertiary referral centre, which covers an important part of Romanian territory and population of patients with acromegaly. Materials and methods: We reviewed the records of all 164 patients (49 males and 115 females; median age 55 [47, 63.5] years) with newly or previously diagnosed acromegaly, who have been assessed at least once in our tertiary referral centre between January 1, 2012 and March 31, 2016. This sample represents 13.6% of the total expected 1200 Romanian patients with acromegaly and covers 82.9% of the counties in Romania. Control of acromegaly was defined as a random serum growth hormone (GH) < 1 ng/mL and an age-normalised serum insulin-like growth factor-I (IGF-I) value. The GH and IGF-I values used for calculation of the control rate were those at the last evaluation. The same assays for GH and IGF-I measurement were used in all patients. Results: There were 147 treated and 17 untreated patients. Of the 147 patients assessed after therapy, 137 (93.2%) had pituitary surgery, 116 (78.9%) were on medical treatment at the last evaluation, and 67 (45.5%) had radiotherapy. Seventy-one (48.3%) had a random GH < 1 ng/mL, 54 (36.7%) had a normalised, age-adjusted IGF-I, and 42 (28.6%) had both normal random serum GH and IGF-I. Conclusions: In Romania, acromegaly benefits from the whole spectrum of therapeutic interventions. However, the control rate remains disappointing.
- Subjects :
- Male
medicine.medical_specialty
Pediatrics
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Population
Endocrinology
Acromegaly
medicine
Humans
Insulin-Like Growth Factor I
education
education.field_of_study
Radiotherapy
Medical treatment
Human Growth Hormone
Romania
business.industry
Disease Management
Rate control
Serum growth hormone
Middle Aged
medicine.disease
Disease control
Surgery
Radiation therapy
Pituitary Gland
Female
Pituitary surgery
business
Subjects
Details
- ISSN :
- 22998306 and 0423104X
- Database :
- OpenAIRE
- Journal :
- Endokrynologia Polska
- Accession number :
- edsair.doi.dedup.....caadb64ce7e68cfbd73b3ad9e0f5bfd3