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Brain Amyloid-β Deposition and Blood Biomarkers in Patients with Clinically Diagnosed Alzheimer's Disease
- Source :
- Journal of Alzheimer's disease : JAD. 69(1)
- Publication Year :
- 2019
-
Abstract
- Brain amyloid-β (Aβ) deposition is a hallmark to define Alzheimer's disease (AD). We investigated the positive rate of brain amyloid deposition assessed with 11C-Pittsburgh compound (PiB)-PET and blood Aβ levels in a cohort of probable AD patients who were diagnosed according to the 1984 NINCDS-ADRDA criteria. Eighty-four subjects with a clinical diagnosis of probable AD dementia, amnestic mild cognitive impairment (MCI), and cognitively normal (CN) status were subjected to PiB-PET and 18F-fluorodeoxyglucose (FDG)-PET scans. Plasma biomarkers of Aβ42, Aβ40, and T-tau were measured using single molecule array technology. The positive rate of PiB-PET, the associations between PiB-PET status and FDG-PET, plasma biomarkers, and clinical manifestations were analyzed. PiB-PET was positive in 77.36% of probable AD patients, 31.80% of MCI patients, and 0 of NC. Plasma Aβ42/Aβ40 ratio was associated with PiB-PET, the ROC curve analysis revealing an AUC of 0.77 (95% CI: 0.66-0.87), with a sensitivity of 82% and specificity of 64%. Some clinical manifestations were associated with PiB-PET imaging. Our findings indicate that only three-fourths of patients diagnosed with probable AD fit the pathological criteria, suggesting that we should be cautious regarding the accuracy of AD diagnosis when no biomarker evidence is available in our clinical practice.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Amyloid beta
tau Proteins
Disease
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
Internal medicine
Medicine
Dementia
Humans
In patient
Cognitive Dysfunction
Pathological
Aged
Amyloid beta-Peptides
biology
business.industry
General Neuroscience
Brain
General Medicine
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Peptide Fragments
Psychiatry and Mental health
Clinical Psychology
030104 developmental biology
Blood biomarkers
Positron-Emission Tomography
Cohort
biology.protein
Disease Progression
Biomarker (medicine)
Female
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Biomarkers
Subjects
Details
- ISSN :
- 18758908
- Volume :
- 69
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's disease : JAD
- Accession number :
- edsair.doi.dedup.....cab14d3bb7c10fcb8c5f3e7dd4a87a85