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Effects of Yizhi Capsule on learning and memory disorder and β-amyloid peptide induced neurotoxicity in rats
- Source :
- Chinese Journal of Integrative Medicine. 12:137-141
- Publication Year :
- 2006
- Publisher :
- Springer Science and Business Media LLC, 2006.
-
Abstract
- Objective: To explore the effects of Yizhi Capsule (YZC) on learning and memory disorder and β-amyloid peptide induced neurotoxicity in rats.Methods: Various doses of YZC were administered to Sprague-Dawley (SD) rats for 8 consecutive days, twice a day. On the 8th day of the experiment, scopolamine hydrobromide was intraperitoneally injected to every rat and Morris water maze test and shuttle dark avoidance test were carried out respectively to explore the changes of learning and memory capacities in the rats. Besides, after the cerebral cortical neurons of newborn SD rats aged within 3 days were culturedin vitro for 7 days, drug serum containing YZC was added to the cultured neurons before or after β amyloid peptide25–35 (Aβ25–35) intoxication to observe the protective effect of YZC on neurotoxicity by MTT assay and to determine the LDH content in the supernatant.Results: Compared with those untreated with YZC, the rats having received YZC treatment got superiority in shorter time of platform seeking in Morris water maze test, as well as elongated latent period and less times of error in shuttle dark avoidance test. On the cultured neurons, YZC drug serum could effectively increase the survival rate of Aβ25–35 intoxicated neurons and reduce the LDH contents in cultured supernatant.Conclusion: YZC has an action of improving learning and memory disorder, and good protective effect on Aβ25–35 induced neurotoxicity in SD rats.
- Subjects :
- Male
Scopolamine
Morris water navigation task
Pharmacology
Rats, Sprague-Dawley
Avoidance Learning
medicine
Animals
Learning
Pharmacology (medical)
MTT assay
Memory disorder
Maze Learning
Cells, Cultured
Cerebral Cortex
Neurons
Memory Disorders
Amyloid beta-Peptides
L-Lactate Dehydrogenase
Plant Extracts
business.industry
Neurotoxicity
General Medicine
medicine.disease
In vitro
Rats
Complementary and alternative medicine
Anesthesia
Alpinia
Female
Yizhi capsule
β amyloid peptide
business
Drugs, Chinese Herbal
Scopolamine Hydrobromide
Subjects
Details
- ISSN :
- 19930402 and 16720415
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Chinese Journal of Integrative Medicine
- Accession number :
- edsair.doi.dedup.....cabde56a4d6b81c832b876044b1ec36f