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Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction

Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction

Authors :
Vladimir A. Kuznetsov
Jean-Paul Kovalik
Sock Cheng Poh
Zhiqun Tang
Sock Hwee Tan
Richard W. Troughton
Alan Yean Yip Fong
Bryan P. Yan
Vitaly Sorokin
Eliana C. Martinez
Chee Tang Chin
Leonardo Carvalho
Ghim Siong Ow
Mark Y. Chan
Aruni Seneviratna
Scott A. Summers
Jianhong Ching
A. Mark Richards
Source :
JACC: Basic to Translational Science, JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 163-175 (2018)
Publication Year :
2017

Abstract

Visual Abstract<br />Highlights • Targeted profiling of ceramides identified a 12-ceramide plasma signature that predicted 12-month cardiovascular death, MI, and stroke in 2 prospective cohorts of AMI patients. • Among coronary artery bypass grafting patients, plasma ceramides were higher in those with recent AMI compared with those without recent acute MI. • Analysis of rat ischemic myocardium revealed a consistent increase in ceramide levels and overexpression of 3 enzymes in ceramide biosynthesis.<br />Summary We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery, those with recent AMI, compared with those without recent AMI, showed a significant increase in 5 of the signature’s 12 ceramides in plasma but not simultaneously-biopsied aortic tissue. In contrast, a rat AMI model, compared with sham control, showed a significant increase in myocardial concentrations of all 12 ceramides and up-regulation of 3 ceramide-producing enzymes, suggesting ischemic myocardium as a possible source of this ceramide signature.

Details

ISSN :
2452302X
Volume :
3
Issue :
2
Database :
OpenAIRE
Journal :
JACC. Basic to translational science
Accession number :
edsair.doi.dedup.....caf597b4705130f82632cf693ec42a03