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Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction
Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction
- Source :
- JACC: Basic to Translational Science, JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 163-175 (2018)
- Publication Year :
- 2017
-
Abstract
- Visual Abstract<br />Highlights • Targeted profiling of ceramides identified a 12-ceramide plasma signature that predicted 12-month cardiovascular death, MI, and stroke in 2 prospective cohorts of AMI patients. • Among coronary artery bypass grafting patients, plasma ceramides were higher in those with recent AMI compared with those without recent acute MI. • Analysis of rat ischemic myocardium revealed a consistent increase in ceramide levels and overexpression of 3 enzymes in ceramide biosynthesis.<br />Summary We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery, those with recent AMI, compared with those without recent AMI, showed a significant increase in 5 of the signature’s 12 ceramides in plasma but not simultaneously-biopsied aortic tissue. In contrast, a rat AMI model, compared with sham control, showed a significant increase in myocardial concentrations of all 12 ceramides and up-regulation of 3 ceramide-producing enzymes, suggesting ischemic myocardium as a possible source of this ceramide signature.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Ceramide
Acute coronary syndrome
lcsh:Diseases of the circulatory (Cardiovascular) system
MACCE, major adverse cardiac and cerebrovascular events
Bypass grafting
Ceramide biosynthesis
Ischemic myocardium
CLINICAL RESEARCH
CAD, coronary artery disease
nSMase, neutral sphingomelinase
030204 cardiovascular system & hematology
SWVg, statistically-weighted voting grouping
acute coronary syndrome
03 medical and health sciences
chemistry.chemical_compound
major adverse cardiovascular and cerebrovascular events
risk prediction
LAD, left anterior descending
0302 clinical medicine
dihydroceramides
Internal medicine
medicine
Myocardial infarction
cardiovascular diseases
SPTLC2, serine palmitoyl transferase-2
DDg, data-driven grouping
ceramides
Myocardial tissue
business.industry
CABG, coronary artery bypass graft
HILIC, hydrophilic interaction LC
medicine.disease
SPT, serine palmitoyl transferase
AMI, acute myocardial infarction
030104 developmental biology
medicine.anatomical_structure
chemistry
lcsh:RC666-701
Cardiology
MI, myocardial infarction
prognosis
Cardiology and Cardiovascular Medicine
business
CerS6, ceramide synthase 6
Artery
Subjects
Details
- ISSN :
- 2452302X
- Volume :
- 3
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- JACC. Basic to translational science
- Accession number :
- edsair.doi.dedup.....caf597b4705130f82632cf693ec42a03