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ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass
- Source :
- Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017), Scientific Reports
- Publication Year :
- 2017
- Publisher :
- Nature Publishing Group, 2017.
-
Abstract
- Chemotherapy promotes the development of cachexia, a debilitating condition characterized by muscle and fat loss. ACVR2B/Fc, an inhibitor of the Activin Receptor 2B signaling, has been shown to preserve muscle mass and prolong survival in tumor hosts, and to increase bone mass in models of osteogenesis imperfecta and muscular dystrophy. We compared the effects of ACVR2B/Fc on muscle and bone mass in mice exposed to Folfiri. In addition to impairing muscle mass and function, Folfiri had severe negative effects on bone, as shown by reduced trabecular bone volume fraction (BV/TV), thickness (Tb.Th), number (Tb.N), connectivity density (Conn.Dn), and by increased separation (Tb.Sp) in trabecular bone of the femur and vertebra. ACVR2B/Fc prevented the loss of muscle mass and strength, and the loss of trabecular bone in femurs and vertebrae following Folfiri administration. Neither Folfiri nor ACVR2B/Fc had effects on femoral cortical bone, as shown by unchanged cortical bone volume fraction (Ct.BV/TV), thickness (Ct.Th) and porosity. Our results suggest that Folfiri is responsible for concomitant muscle and bone degeneration, and that ACVR2B/Fc prevents these derangements. Future studies are required to determine if the same protective effects are observed in combination with other anticancer regimens or in the presence of cancer.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Cachexia
Bone density
Drug-Related Side Effects and Adverse Reactions
Activin Receptors, Type II
Leucovorin
lcsh:Medicine
Antineoplastic Agents
Mice, Inbred Strains
Article
Bone and Bones
Muscular Dystrophies
03 medical and health sciences
Mice
Drug Therapy
Bone Density
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Animals
Femur
Muscular dystrophy
Muscle, Skeletal
lcsh:Science
Multidisciplinary
Chemistry
lcsh:R
Induction Chemotherapy
medicine.disease
3. Good health
Vertebra
030104 developmental biology
medicine.anatomical_structure
Endocrinology
Osteogenesis imperfecta
FOLFIRI
Cortical bone
Camptothecin
Female
lcsh:Q
Fluorouracil
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 7
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....cb25658e283acb3538d2272b670f2746