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Longitudinal optic neuritis-unrelated visual evoked potential changes in NMO spectrum disorders
- Source :
- Neurology, Neurology, 2020, 94 (4), pp.e407-e418. ⟨10.1212/WNL.0000000000008684⟩, Neurology, American Academy of Neurology, 2020, 94 (4), pp.e407-e418. ⟨10.1212/WNL.0000000000008684⟩
- Publication Year :
- 2019
-
Abstract
- ObjectiveTo investigate if patients with neuromyelitis optica spectrum disorder (NMOSD) develop subclinical visual pathway impairment independent of acute attacks.MethodsA total of 548 longitudinally assessed full-field visual evoked potentials (VEP) of 167 patients with NMOSD from 16 centers were retrospectively evaluated for changes of P100 latencies and P100-N140 amplitudes. Rates of change in latencies (RCL) and amplitudes (RCA) over time were analyzed for each individual eye using linear regression and compared using generalized estimating equation models.ResultsThe rates of change in the absence of optic neuritis (ON) for minimal VEP intervals of ≥3 months between baseline and last follow-up were +1.951 ms/y (n = 101 eyes; SD = 6.274; p = 0.012) for the P100 latencies and −2.149 µV/y (n = 64 eyes; SD = 5.013; p = 0.005) for the P100-N140 amplitudes. For minimal VEP intervals of ≥12 months, the RCL was +1.768 ms/y (n = 59 eyes; SD = 4.558; p = 0.024) and the RCA was −0.527 µV/y (n = 44 eyes; SD = 2.123; p = 0.111). The history of a previous ON >6 months before baseline VEP had no influence on RCL and RCA. ONs during the observational period led to mean RCL and RCA of +11.689 ms/y (n = 16 eyes; SD = 17.593; p = 0.003) and −1.238 µV/y (n = 11 eyes; SD = 3.708; p = 0.308), respectively.ConclusionThis first longitudinal VEP study of patients with NMOSD provides evidence of progressive VEP latency delay occurring independently of acute ON. Prospective longitudinal studies are needed to corroborate these findings and help to interpret the clinical relevance.
- Subjects :
- medicine.medical_specialty
Neuromyelitis optica
business.industry
Multiple sclerosis
Medizin
Visual evoked potentials
medicine.disease
Observational period
03 medical and health sciences
0302 clinical medicine
Ophthalmology
030221 ophthalmology & optometry
medicine
Optic neuritis
Neurology (clinical)
Evoked potential
NMO Spectrum Disorders
business
030217 neurology & neurosurgery
ComputingMilieux_MISCELLANEOUS
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Subclinical infection
Subjects
Details
- Language :
- English
- ISSN :
- 00283878 and 1526632X
- Database :
- OpenAIRE
- Journal :
- Neurology, Neurology, 2020, 94 (4), pp.e407-e418. ⟨10.1212/WNL.0000000000008684⟩, Neurology, American Academy of Neurology, 2020, 94 (4), pp.e407-e418. ⟨10.1212/WNL.0000000000008684⟩
- Accession number :
- edsair.doi.dedup.....cb3376da0d5f35444d632b59d1849fdf