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Tissue-engineered injectable bone regeneration for osseointegrated dental implants
- Source :
- Clinical oral implants research. 15(5)
- Publication Year :
- 2004
-
Abstract
- The present study investigated a correlation between osseointegration in dental implants and an injectable tissue-engineered bone, using mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP). Initially, the teeth in the mandible region were extracted and the healing period was 1 month. Bone defects on both sides of the mandible were prepared with a trephine bar. The defects were implanted with graft materials as follows: PRP, dog MSCs (dMSCs), and PRP, autogenous particulate cancellous bone and marrow (PCBM), and control (defect only). Two months later, the animals were evaluated by histology, and at the same time dental implants were installed. Two months later, the animals were sacrificed and nondecalcified sections were evaluated histologically and histometrically. According to the histological observations, the dMSCs/PRP group had well-formed mature bone and neovascularization, compared with the control (defect only) and PRP groups, as was the same for the PCBM group. A higher marginal bone level was observed around implants with PRP, PCBM, and dMSCs/PRP compared with the control. Furthermore, the values describing the amount of bone-implant contact (BIC) at the bone/implant interface were significantly different between the PRP, PCBM, dMSCs/PRP, and control groups. Significant differences were also found between the dMSCs/PRP and control groups in bone density. The findings of this experimental study indicate that the use of a mixture of dMSCs/PRP results in good results such as the amount of BIC and bone density comparable with that achieved by PCBM.
- Subjects :
- Mature Bone
Bone Regeneration
Bone density
Cephalometry
Surface Properties
medicine.medical_treatment
Dentistry
Neovascularization, Physiologic
Mandible
Platelet Transfusion
Mesenchymal Stem Cell Transplantation
Osseointegration
Dogs
Bone Density
Osteogenesis
medicine
Animals
Tooth Socket
Dental implant
Bone Marrow Transplantation
Dental Implants
Bone Transplantation
Tissue Engineering
business.industry
medicine.anatomical_structure
Trephine
Platelet-rich plasma
Implant
Oral Surgery
business
Cancellous bone
Subjects
Details
- ISSN :
- 09057161
- Volume :
- 15
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Clinical oral implants research
- Accession number :
- edsair.doi.dedup.....cb4811e60aef47d0d987decc4087aea6