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Humoral response to <scp>mRNA</scp> ‐based <scp>COVID</scp> ‐19 vaccine in patients with myeloid malignancies

Humoral response to <scp>mRNA</scp> ‐based <scp>COVID</scp> ‐19 vaccine in patients with myeloid malignancies

Authors :
Akio Mori
Masahiro Onozawa
Shihori Tsukamoto
Takashi Ishio
Emi Yokoyama
Koh Izumiyama
Makoto Saito
Haruna Muraki
Masanobu Morioka
Takanori Teshima
Takeshi Kondo
Source :
British Journal of Haematology. 197:691-696
Publication Year :
2022
Publisher :
Wiley, 2022.

Abstract

Data on the response to the COVID-19 vaccine in patients with myeloid malignancy, who are at severe risk in case of infection, have not emerged. In a study of 69 patients with myeloid malignancies, including 46 patients with acute myeloid leukaemia (AML) and 23 patients with myelodysplastic syndrome (MDS), anti-spike SARS-CoV-2 antibody titres were measured 3 months after the second mRNA-based vaccination. Seroconversion rates for AML and MDS were 94.7% and 100% respectively, with no significant difference from healthy controls (HCs). Patients with MDS showed a significantly lower antibody titre than that in HCs or AML patients. In AML patients, the antibody titres were comparable to those in HCs when treatment was completed, but lower in patients under maintenance therapy. The response to COVID-19 vaccine appears to be related to disease and treatment status. Patients with myeloid malignancies may be more responsive to vaccines than patients with lymphoid malignancies.

Details

ISSN :
13652141 and 00071048
Volume :
197
Database :
OpenAIRE
Journal :
British Journal of Haematology
Accession number :
edsair.doi.dedup.....cb52e55f33804768a5de1f637827a975
Full Text :
https://doi.org/10.1111/bjh.18138