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Experimental infection of rhesus monkeys with SIV isolated from African green monkeys

Authors :
Ottmar Herchenröder
Christiane Stahl-Hennig
Wolfgang Lüke
Josef Schneider
Gabriele Schulze
Heinz Hartmann
Heidemarie Schmidt
Klara Tenner-Racz
Paul Racz
Masanori Hayami
John C. Kelliher
Gerhard Hunsmann
Source :
Intervirology. 30
Publication Year :
1989

Abstract

To establish an animal model for AIDS, 6 juvenile rhesus monkeys were infected intravenously with cell-free SIVagmTYO-1, 5, or 7. One animal was infected with SIV of known pathogenicity isolated from a sooty mangabey (SIVsmm). The 2 animals infected with TYO-1, 1 of 2 infected with TYO-7 and the 1 infected with SIVsmm seroconverted within 4-8 weeks after infection and infectious virus could be recovered 8-10 or 44 weeks after infection. Three of the 4 seroconverted monkeys developed a persistent lymphadenopathy 12 weeks after infection. Rhesus monkeys infected with SIVagm could serve as a model to study HIV infection and for vaccine trials.

Details

ISSN :
03005526
Volume :
30
Database :
OpenAIRE
Journal :
Intervirology
Accession number :
edsair.doi.dedup.....cb6814dbe8dafbef6c7acb079d2a595d