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Experimental infection of rhesus monkeys with SIV isolated from African green monkeys
- Source :
- Intervirology. 30
- Publication Year :
- 1989
-
Abstract
- To establish an animal model for AIDS, 6 juvenile rhesus monkeys were infected intravenously with cell-free SIVagmTYO-1, 5, or 7. One animal was infected with SIV of known pathogenicity isolated from a sooty mangabey (SIVsmm). The 2 animals infected with TYO-1, 1 of 2 infected with TYO-7 and the 1 infected with SIVsmm seroconverted within 4-8 weeks after infection and infectious virus could be recovered 8-10 or 44 weeks after infection. Three of the 4 seroconverted monkeys developed a persistent lymphadenopathy 12 weeks after infection. Rhesus monkeys infected with SIVagm could serve as a model to study HIV infection and for vaccine trials.
- Subjects :
- Acquired Immunodeficiency Syndrome
Cercopithecidae
Simian immunodeficiency virus
Biology
Pathogenicity
medicine.disease_cause
medicine.disease
Antibodies, Viral
Virology
Macaca mulatta
Disease Models, Animal
Infectious Diseases
Animal model
Acquired immunodeficiency syndrome (AIDS)
medicine
Juvenile
Animals
Macaca
Simian Immunodeficiency Virus
African Green Monkey
Lymph Nodes
Viremia
Retroviridae Infections
Subjects
Details
- ISSN :
- 03005526
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Intervirology
- Accession number :
- edsair.doi.dedup.....cb6814dbe8dafbef6c7acb079d2a595d