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Caldesmon is essential for cardiac morphogenesis and function: In vivo study using a zebrafish model
- Source :
- Biochemical & Biophysical Research Communications, 378(1), 37-40. Academic Press
- Publication Year :
- 2009
-
Abstract
- The zebrafish homologue of caldesmon is similar to the mammalian low molecular weight caldesmon (l-CaD). In this study, we explored the effects of caldesmon knockdown on vertebrate heart development in vivo. In a zebrafish model caldesmon was knocked down resulting in defective cardiac morphogenesis, muscularization and function. The data provide the first functional assessment of the role of caldesmon in cardiac development in vivo, and indicate that caldesmon is essential for proper cardiac organogenesis and function. Because caldesmon expression remarkably influences cardiac muscularization, the findings are relevant for designing future therapeutic strategies in the regeneration of cardiac damage. (C) 2008 Elsevier Inc. All rights reserved
- Subjects :
- medicine.medical_specialty
animal structures
Biophysics
Organogenesis
Biochemistry
In vivo
Internal medicine
Morphogenesis
medicine
Animals
Molecular Biology
Zebrafish
Gene knockdown
biology
Heart development
Myogenesis
Regeneration (biology)
Heart
Cell Biology
Zebrafish Proteins
biology.organism_classification
musculoskeletal system
Cell biology
Caldesmon
Endocrinology
Gene Knockdown Techniques
Models, Animal
cardiovascular system
biology.protein
Calmodulin-Binding Proteins
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 378
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Biochemical & Biophysical Research Communications
- Accession number :
- edsair.doi.dedup.....cb6b577844b9807bb5ed3835a18b25d1