Colistin resistance superimposed to endemic carbapenem-resistant Klebsiella pneumoniae: a rapidly evolving problem in Italy, November 2013 to April 2014

Authors :: Monaco, M
Giani, T
Raffone, M
Arena, F
Garcia Fernandez, A
Pollini, S
Network EuSCAPE Italy
Grundmann, H
Pantosti, A
Rossolini, Gm
Collaborators
Barbaro, A
Campion, L
Catania, M
De Bernochi, A
Di Taranto AM
Dusi, P
Grandesso, S
Luzzaro, F
Manso, E
Meledandri, M
Mencacci, A
Milano, F
Parisi, G
Pecile, P
Restelli, A
Rocchetti, A
Arrigo, C
Rossi, M
Santino, Iolanda
Sarti, M
Sartor, A.
Source :: Europe PubMed Central, Scopus-Elsevier
Publication Year :: 2014
Publisher :: European Centre for Disease Control and Prevention (ECDC), 2014.
Abstract: Consecutive non-replicate clinical isolates (n=191) of carbapenem non-susceptible Enterobacteriaceae were collected from 21 hospital laboratories across Italy from November 2013 to April 2014 as part of the European Survey on Carbapenemase-producing Enterobacteriaceae (EuSCAPE) project. Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP) represented 178 (93%) isolates with 76 (43%) respectively resistant to colistin, a key drug for treating carbapenamase-producing Enterobacteriaceae. KPC-KP colistin-resistant isolates were detected in all participating laboratories. This underscores a concerning evolution of colistin resistance in a setting of high KPC-KP endemicity.

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