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Mitosis Phase Enrichment with Identification of Mitotic Centromere-Associated Kinesin As a Therapeutic Target in Castration-Resistant Prostate Cancer
- Source :
- PLoS ONE, PLoS ONE, Vol 7, Iss 2, p e31259 (2012)
- Publication Year :
- 2012
- Publisher :
- Public Library of Science, 2012.
-
Abstract
- The recently described transcriptomic switch to a mitosis program in castration-resistant prostate cancer (CRPC) suggests that mitotic proteins may be rationally targeted at this lethal stage of the disease. In this study, we showed upregulation of the mitosis-phase at the protein level in our cohort of 51 clinical CRPC cases and found centrosomal aberrations to also occur preferentially in CRPC compared with untreated, high Gleason-grade hormone-sensitive prostate cancer (P
- Subjects :
- Male
Urology
Cancer Treatment
lcsh:Medicine
Kinesins
Mitosis
Antineoplastic Agents
Biology
urologic and male genital diseases
Transcriptome
Prostate cancer
Downregulation and upregulation
medicine
Humans
Castration
Molecular Targeted Therapy
lcsh:Science
Centrosome
Gene knockdown
Multidisciplinary
lcsh:R
Prostate Diseases
Cancers and Neoplasms
Prostatic Neoplasms
medicine.disease
Molecular biology
Up-Regulation
Gene expression profiling
Genitourinary Tract Tumors
Oncology
Drug Resistance, Neoplasm
Cancer research
Androgens
Kinesin
Medicine
lcsh:Q
Neoplasm Grading
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 7
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....cb979f6723a627a74b5bef9769b03e69