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Low platelet count as risk factor for infections in patients with primary immune thrombocytopenia: a retrospective evaluation
- Source :
- Annals of hematology, 97(9), 1701-1706. Springer Verlag, Annals of Hematology, Annals of Hematology, 97(9), 1701-1706. Springer-Verlag
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Infectious complications are common and sometimes life threatening in patients with immune thrombocytopenia (ITP), mainly due to the immune-suppressive therapy. Recent evidence suggests a potential role of platelets in the inflammation process. In this clinical study, we further investigated the role of thrombocytopenia on infections in patients with primary ITP. We retrospectively evaluated data from the recently published large randomized clinical trial of a cohort of 195 patients with primary ITP, who were randomized for prednisone or high-dose dexamethasone. From 158 patients (81%), data on platelet count and infections within the first month of treatment were collected. In this period, 24% of the ITP patients had an infection. Patients with infection had significant lower platelet counts during the first month of treatment leading to a significant lower therapy response at 1 month and a significant longer hospital stay (14.0 versus 9.8 days). Additionally, Cox regression analysis showed that an increase in platelet count of 20 × 109/L led to a reduction of 52% in infections in the next week, showing low platelet count is a significant risk factor for infection. Platelet transfusion led to an increase in platelet count in ITP patients without infection, but not in patients with infection. In conclusion, infections are common in patients with primary ITP leading to significant worse response rates and a longer hospital stay. Interestingly, low platelet count was independently correlated with an increased risk of infection.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Platelet Transfusion
030204 cardiovascular system & hematology
Infections
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
Risk Factors
Prednisone
law
hemic and lymphatic diseases
Internal medicine
medicine
Humans
Platelet
Risk factor
Dexamethasone
Retrospective Studies
Purpura, Thrombocytopenic, Idiopathic
Hematology
Platelet Count
business.industry
Incidence
General Medicine
Length of Stay
Middle Aged
Thrombocytopenia
030104 developmental biology
Platelet transfusion
Cohort
ITP
Original Article
Female
Infection
business
medicine.drug
Subjects
Details
- ISSN :
- 14320584 and 09395555
- Volume :
- 97
- Database :
- OpenAIRE
- Journal :
- Annals of Hematology
- Accession number :
- edsair.doi.dedup.....cba458f90d824fb1a91965ceb08e7f9d