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Molecular markers and biological targeted therapies in metastatic colorectal cancer: expert opinion and recommendations derived from the 11th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2009
- Source :
- Annals of Oncology : Official Journal of the European Society for Medical Oncology / ESMO
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- The article summarizes the expert discussion and recommendations on the use of molecular markers and of biological targeted therapies in metastatic colorectal cancer (mCRC), as well as a proposed treatment decision strategy for mCRC treatment. The meeting was conducted during the 11th ESMO/World Gastrointestinal Cancer Congress (WGICC) in Barcelona in June 2009. The manuscript describes the outcome of an expert discussion leading to an expert recommendation. The increasing knowledge on clinical and molecular markers and the availability of biological targeted therapies have major implications in the optimal management in mCRC. 21 Suppl 6 vi1 10
- Subjects :
- Oncology
Colorectal cancer
medicine.medical_treatment
Braf protein
Gastroenterology
Metastasis
Drug antagonism
Targeted therapy
Antineoplastic agents
Pathology
Conference paper
Biological markers
Predictive marker
Hematology
Prognosis
Chemotherapy regimen
Antineoplastic agent
Proto-oncogene proteins
Ras protein
Human
Receptor
medicine.medical_specialty
Neoplasm metastasis
Ras proteins
MEDLINE
Oncoprotein
Colorectal neoplasms
Proto-oncogene proteins b-raf
Internal medicine
Genetics
medicine
Humans
Gastrointestinal cancer
Colorectal tumor
B raf kinase
Epidermal growth factor receptor
Kras protein
business.industry
Epidermal growth factor
Cancer
medicine.disease
digestive system diseases
Biological marker
Metabolism
Spain
Mutation
Carcinoembryonic antigen
Microsatellite instability
business
Subjects
Details
- ISSN :
- 09237534
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Annals of Oncology
- Accession number :
- edsair.doi.dedup.....cbacd7b9ee1ebf6fa145eb7d60aaa564
- Full Text :
- https://doi.org/10.1093/annonc/mdq273