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Clinical and Pathological Aspects of Hemophilia A in Japanese Brown Cattle
- Source :
- Journal of Veterinary Medical Science. 70:293-296
- Publication Year :
- 2008
- Publisher :
- Japanese Society of Veterinary Science, 2008.
-
Abstract
- A coagulopathy with subcutaneous bleeding and muscular or peritracheal/periesophageal bleeding occurred in two male Japanese Brown calves of the same dam. One of the affected calves died three days after the onset of bleeding and the other survived normally until being slaughtered despite once suffering from subcutaneous hematoma. Hemostatic tests of the latter case showed prolonged activated partial thromboplastin time (APTT), and severely reduced factor VIII activity. In addition, von Willebrand factor activity, determined by the human platelet aggregation test, was within the normal range; therefore, the calf was diagnosed with hemophilia A. These are the first bovine cases of hemophilia A definitely diagnosed clinicopathologically.
- Subjects :
- Male
medicine.medical_specialty
Cattle Diseases
Hemophilia A
Fatal Outcome
hemic and lymphatic diseases
von Willebrand Factor
Coagulopathy
Animals
Medicine
Reduced factor VIII activity
Subcutaneous hematoma
Pathological
Normal range
Factor VIII
General Veterinary
medicine.diagnostic_test
business.industry
medicine.disease
Surgery
Japanese Brown cattle
Von Willebrand factor.activity
Cattle
Partial Thromboplastin Time
business
Partial thromboplastin time
Subjects
Details
- ISSN :
- 13477439 and 09167250
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Journal of Veterinary Medical Science
- Accession number :
- edsair.doi.dedup.....cbe03610fecbb4d443d76e73a59b7f8f