Back to Search
Start Over
Liquid biopsy from research to clinical practice: focus on non-small cell lung cancer
- Source :
- EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, r-FIHGUV. Repositorio Institucional de Producción Científica de la Fundación de Investigación del Hospital General de Valencia, instname
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- INTRODUCTION: In the current era of personalized medicine, liquid biopsy has acquired a relevant importance in patient management of advanced stage non-small cell lung cancer (NSCLC). As a matter of fact, liquid biopsy may supplant the problem of inadequate tissue for molecular testing. The term 'liquid biopsy' refers to a number of different biological fluids, but is most clearly associated with plasma-related platforms. It must be taken into account that pre-analytical processing and the selection of the appropriate technology according to the clinical context may condition the results obtained. In addition, novel clinical applications beyond the evaluation of the molecular status of predictive biomarkers are currently under investigation. AREAS COVERED: This review summarizes the available evidence on pre-analytical issues and different clinical applications of liquid biopsies in NSCLC patients. EXPERT OPINION: Liquid biopsy should be considered not only as a valid alternative but as complementary to tissue-based molecular approaches. Careful attention should be paid to the optimization and standardization of all phases of liquid biopsy samples management in order to determine a significant improvement in either sensitivity or specificity, while significant reducing the number of 'false negative' or 'false positive' molecular results.
- Subjects :
- medicine.medical_specialty
Lung Neoplasms
Context (language use)
NSCLC
Pathology and Forensic Medicine
Carcinoma, Non-Small-Cell Lung
Biomarkers, Tumor
Genetics
medicine
Humans
In patient
Precision Medicine
Liquid biopsy
Intensive care medicine
Lung cancer
Molecular Biology
Predictive biomarker
liquid biopsy
business.industry
biomarkers
ctDNA
medicine.disease
CTC
Clinical Practice
biomarker
Molecular Medicine
Personalized medicine
Non small cell
business
Subjects
Details
- ISSN :
- 17448352 and 14737159
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Expert Review of Molecular Diagnostics
- Accession number :
- edsair.doi.dedup.....cc15eec172af194d6aecbf27f0510f71