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Normal and abnormal development of the aortic wall and valve: correlation with clinical entities
- Source :
- Netherlands Heart Journal, 22(9), 363-369, Netherlands Heart Journal
- Publication Year :
- 2014
-
Abstract
- Dilation of the wall of the thoracic aorta can be found in patients with a tricuspid (TAV) as well as a bicuspid aortic valve (BAV) with and without a syndromic component. BAV is the most common congenital cardiovascular malformation, with a population prevalence of 0.5-2 %. The clinical course is often characterised by aneurysm formation and in some cases dissection. The non-dilated aortic wall is less well differentiated in all BAV as compared with TAV, thereby conferring inherent developmental susceptibility. Furthermore, a turbulent flow, caused by the inappropriate opening of the bicuspid valve, could accelerate the degenerative process in the aortic wall. However, not all patients with bicuspidy develop clinical complications during their life. We postulate that the increased vulnerability for aortic complications in a subset of patients with BAV is caused by a defect in the early development of the aorta and aortic valve. This review discusses histological and molecular genetic aspects of the normal and abnormal development of the aortic wall and semilunar valves. Aortopathy associated with BAV could be the result of a shared developmental defect during embryogenesis.
- Subjects :
- Aortic valve
medicine.medical_specialty
Aorta
education.field_of_study
Embryology
Bicuspid aortic valve
business.industry
Population
Clinical course
Review Article
medicine.disease
Aortic wall
medicine.anatomical_structure
Bicuspid valve
Internal medicine
medicine.artery
Aortopathy
Cardiology
medicine
cardiovascular system
Thoracic aorta
business
education
Cardiology and Cardiovascular Medicine
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Netherlands Heart Journal, 22(9), 363-369, Netherlands Heart Journal
- Accession number :
- edsair.doi.dedup.....cc1750dc9aefd43c5b0239d1458a07df