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Shear Wave Elastography of Breast Lesions: Quantitative Analysis of Elastic Heterogeneity Improves Diagnostic Performance
- Source :
- Ultrasound in medicinebiology. 45(8)
- Publication Year :
- 2019
-
Abstract
- The aim of this study was to evaluate whether quantitative analysis of elastic heterogeneity (EH) could improve the diagnostic performance of shear wave elastography (SWE) in breast lesions. From August 2016 to August 2017, 280 patients were enrolled in this prospective study. All lesions were evaluated with the ultrasound Breast Imaging Reporting and Data System (BI-RADS) and SWE with Virtual Touch tissue imaging quantification. The shear wave velocity (SWV) of the three areas of highest stiffness and lowest stiffness within the lesions were measured to calculate the maximum SWV (SWVmax), mean SWV (SWVmean) and EH. The EH was determined as the difference between the averaged highest SWV and lowest SWV. The diagnostic performance-including the area under the receiver operating characteristic curve (AUC) and the sensitivity and specificity of BI-RADS, EH, SWVmax and SWVmean-were analyzed. The AUC of EH, SWVmax and SWVmean were 0.963, 0.949 and 0.937, respectively. The sensitivity of EH was 93.75%, which was significantly higher than that of SWVmax (84.37%) and SWVmean (84.37%) (p 0.05). For category 4A lesions, EH predicted all the malignant lesions, while two cancers were misdiagnosed by SWVmax and SWVmean, respectively. Quantitative analysis of EH can improve the sensitivity of SWE for the differential diagnosis of breast lesions without loss of specificity.
- Subjects :
- Adult
Acoustics and Ultrasonics
Adolescent
Tissue imaging
Biophysics
Breast Neoplasms
Sensitivity and Specificity
030218 nuclear medicine & medical imaging
Diagnosis, Differential
03 medical and health sciences
Young Adult
0302 clinical medicine
Medicine
Humans
Radiology, Nuclear Medicine and imaging
Breast
Prospective Studies
Aged
Aged, 80 and over
Shear wave elastography
Radiological and Ultrasound Technology
Receiver operating characteristic
medicine.diagnostic_test
business.industry
Wave velocity
Reproducibility of Results
Middle Aged
030220 oncology & carcinogenesis
Elasticity Imaging Techniques
Female
Elastography
Ultrasonography, Mammary
business
Nuclear medicine
Quantitative analysis (chemistry)
Ultrasound breast
Subjects
Details
- ISSN :
- 1879291X
- Volume :
- 45
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Ultrasound in medicinebiology
- Accession number :
- edsair.doi.dedup.....cc3f43d0ac4cf62a170c5ca3de132702