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Infection-activated lipopeptide nanotherapeutics with adaptable geometrical morphology for in vivo bacterial ablation

Authors :
Qi-Hang Yu
Rong Huang
Kai-Yue Wu
Xiao-Le Han
Yin-Jia Cheng
Wen-Long Liu
Ai-Qing Zhang
Si-Yong Qin
Source :
Acta Biomaterialia. 154:359-373
Publication Year :
2022
Publisher :
Elsevier BV, 2022.

Abstract

The nonselective membrane disruption of antimicrobial peptides (AMPs) helps in combating the antibacterial resistance. But their overall positive charges lead to undesirable hemolysis and toxicity toward normal living cells, as well as the rapid clearance from blood circulation. In consequence, developing smart AMPs to optimize the antimicrobial outcomes is highly urgent. Relying on the local acidity of microbial infection sites, in this work, we designed an acidity-triggered charge reversal nanotherapeutics with adaptable geometrical morphology for bacterial targeting and optimized therapy. C

Details

ISSN :
17427061
Volume :
154
Database :
OpenAIRE
Journal :
Acta Biomaterialia
Accession number :
edsair.doi.dedup.....cc3fb8555380cafde66b82185c404626