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Clinical outcome of pelvic exenteration in patients with advanced or recurrent uterine cervical cancer
- Source :
- International Journal of Clinical Oncology. 19:133-138
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- Pelvic exenteration has attained an important role in the treatment of advanced or recurrent cervical cancer for obtaining a complete cure or longer disease-free survival. The purpose of this study was to evaluate patients undergoing pelvic exenteration and to determine the clinical features associated with outcome and survival.We retrospectively analyzed the records of 12 patients who underwent pelvic exenteration for uterine cervical cancer between July 2002 and August 2011.Two patients had primary stage IVA cervical adenocarcinoma and 10 patients had recurrent cervical cancer. Eight patients underwent anterior pelvic exenteration, 3 patients underwent total pelvic exenteration, and 1 patient underwent posterior pelvic exenteration. With a median duration of follow-up of 22 months (range 3-116 months), 5 patients were alive without recurrence. Of 5 patients with no evidence of disease, 4 were recurrent or residual tumor, all of whom had common factors, such as a tumor size ≤ 30 mm, negative surgical margins, complete resection, and no lymph node involvement. The 5-year overall survival rate for 12 patients was 42.2 %. Ileus was the most common complication (42 %) and post-operative intestinal anastomosis leaks developed in 3 patients, but no ureteral anastomosis leaks occurred.Pelvic exenteration is a feasible surgical procedure in advanced and/or recurrent cervical cancer patients with no associated post-operative mortality, and the only therapeutic option for complete cure or long-term survival; however, post-operative complications frequently occur.
- Subjects :
- Adult
medicine.medical_specialty
Uterine cervical cancer
medicine.medical_treatment
Uterine Cervical Neoplasms
Recurrent cervical cancer
Disease-Free Survival
Postoperative Complications
Surgical oncology
Humans
Medicine
In patient
Aged
Neoplasm Staging
Positron Emission Tomography-Computed Tomography
Pelvic exenteration
business.industry
Urinary diversion
Hematology
General Medicine
Middle Aged
Pelvic Exenteration
Surgery
Treatment Outcome
Oncology
Female
Neoplasm staging
Neoplasm Recurrence, Local
business
Subjects
Details
- ISSN :
- 14377772 and 13419625
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- International Journal of Clinical Oncology
- Accession number :
- edsair.doi.dedup.....cc49c66ac0ca9b175eac0b4a949198e1