Back to Search
Start Over
A Calcitonin-Negative Neuroendocrine Tumor Derived from Follicular Lesions of the Thyroid
- Source :
- Endocrinology and Metabolism, Vol 30, Iss 2, Pp 221-225 (2015), Endocrinology and Metabolism
- Publication Year :
- 2015
- Publisher :
- Academya Publishing Co., 2015.
-
Abstract
- Neuroendocrine lesions of the thyroid are rare. The most common types are medullary thyroid carcinomas (MTCs) and C-cell hyperplasia. MTCs originate from thyroid parafollicular cells that secrete calcitonin which serves as a serum marker of MTCs. Here, the rare case of a calcitonin-negative neuroendocrine tumor (NET) derived from follicular lesions of the thyroid is described. A 34-year-old man presented at our hospital for the surgical management of an incidental thyroid nodule that was observed on an ultrasound sonography (USG) of the neck. Initially, USG-guided aspiration cytology was performed, and a MTC was suspected. The expressions of thyroglobulin and thyroid transcription factor-1, which are thyroid follicular cell markers, and synaptophysin and chromogranin A, which are neuroendocrine markers, was confirmed following surgical pathology. However, the staining of calcitonin, a marker of MTCs, was not observed. A nonmedullary NET of the thyroid is uncommon, and the distinction between calcitonin-negative NETs and MTCs of the thyroid may be important due to differences in their clinical courses and management.
- Subjects :
- Calcitonin
Pathology
medicine.medical_specialty
endocrine system
endocrine system diseases
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Case Report
Neuroendocrine tumors
Follicular cell
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Thyroid carcinoma
Endocrinology
Medicine
Carcinoma, medullary
lcsh:RC648-665
biology
business.industry
Thyroid
medicine.disease
medicine.anatomical_structure
Medullary carcinoma
Synaptophysin
biology.protein
Thyroglobulin
business
Subjects
Details
- Language :
- English
- ISSN :
- 20935978
- Volume :
- 30
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Endocrinology and Metabolism
- Accession number :
- edsair.doi.dedup.....cc6018c52f3019dbb4de74444827ca61