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The Complexity of FGF23 Effects on Cardiomyocytes in Normal and Uremic Milieu
- Source :
- Cells, Vol 10, Iss 1266, p 1266 (2021), Cells
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Fibroblast growth factor-23 (FGF23) appears to be one of the most promising biomarkers and predictors of cardiovascular risk in patients with heart disease and normal kidney function, but moreover in those with chronic kidney disease (CKD). This review summarizes the current knowledge of FGF23 mechanisms of action in the myocardium in the physiological and pathophysiological state of CKD, as well as its cross-talk to other important signaling pathways in cardiomyocytes. In this regard, current therapeutic possibilities and future perspectives are also discussed.
- Subjects :
- 0301 basic medicine
10017 Institute of Anatomy
Heart disease
QH301-705.5
klotho
Wnt pathway
Renal function
610 Medicine & health
cardiomyocyte
2700 General Medicine
Review
030204 cardiovascular system & hematology
Bioinformatics
urologic and male genital diseases
03 medical and health sciences
FGF signaling
0302 clinical medicine
FGF23
Animals
Humans
Medicine
Myocytes, Cardiac
In patient
Renal Insufficiency, Chronic
Biology (General)
Klotho
business.industry
Wnt signaling pathway
General Medicine
medicine.disease
Pathophysiology
Fibroblast Growth Factors
Fibroblast Growth Factor-23
stomatognathic diseases
030104 developmental biology
570 Life sciences
biology
Signal transduction
business
Biomarkers
Kidney disease
Subjects
Details
- Language :
- English
- ISSN :
- 20734409
- Volume :
- 10
- Issue :
- 1266
- Database :
- OpenAIRE
- Journal :
- Cells
- Accession number :
- edsair.doi.dedup.....cc7c4f1db8cc249d4e382e9059bb94e7