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'Silent' kidney stones in 'asymptomatic' primary hyperparathyroidism—a comparison of multidetector computed tomography and ultrasound
- Source :
- Langenbeck's Archives of Surgery
- Publisher :
- Springer Nature
-
Abstract
- Purpose The purpose of this study was to demonstrate the high number of kidney stones in primary hyperparathyroidism (PHPT) and the low number of in fact “asymptomatic” patients. Methods Forty patients with PHPT (28 female, 12 male; median age 58 (range 33–80) years; interquartile range 17 years [51–68]) without known symptoms of kidney stones prospectively underwent multidetector computed tomography (MDCT) and ultrasound (US) examinations of the urinary tract prior to parathyroid surgery. Images were evaluated for the presence and absence of stones, as well as for the number of stones and sizes in the long axis. The MDCT and US examinations were interpreted by two experienced radiologists who were blinded to all clinical and biochemical data. Statistical analysis was performed using the Wilcoxon signed-rank test. Results US revealed a total of 4 kidney stones in 4 (10 %) of 40 patients (median size 6.5 mm, interquartile range 11.5 mm). MDCT showed a total of 41 stones (median size was 3 mm, interquartile range 2.25 mm) in 15 (38 %) of 40 patients. The number of kidney stones detected with MDCT was significantly higher compared to US (p = 0.00124). Conclusions MDCT is a highly sensitive method for the detection of “silent” kidney stones in patients with PHPT. By widely applying this method, the number of asymptomatic courses of PHPT may be substantially reduced. MDCT should be used primarily to detect kidney stones in PHPT and to exclude asymptomatic PHPT.
- Subjects :
- Parathyroidectomy
Adult
Male
medicine.medical_specialty
endocrine system diseases
medicine.medical_treatment
Kidney stones
Primary hyperparathyroidism
030209 endocrinology & metabolism
Asymptomatic
03 medical and health sciences
Kidney Calculi
0302 clinical medicine
Predictive Value of Tests
Multidetector Computed Tomography
medicine
Humans
Prospective Studies
Prospective cohort study
Asymptomatic hyperparathyroidism
Aged
Ultrasonography
Aged, 80 and over
business.industry
Ultrasound
Middle Aged
medicine.disease
Hyperparathyroidism, Primary
PHPT
030220 oncology & carcinogenesis
Predictive value of tests
Female
Original Article
Surgery
Radiology
medicine.symptom
business
Abdominal surgery
Subjects
Details
- Language :
- English
- ISSN :
- 14352443
- Volume :
- 402
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Langenbeck's Archives of Surgery
- Accession number :
- edsair.doi.dedup.....cc80b7de6b47c38f8312dc99bb97de30
- Full Text :
- https://doi.org/10.1007/s00423-016-1520-2