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Vascularization of the developing chick limb bud: role of the TGFbeta signalling pathway
- Source :
- Journal of Anatomy. 202:93-103
- Publication Year :
- 2003
- Publisher :
- Wiley, 2003.
-
Abstract
- The developing vertebrate limb has fascinated developmental biologists and theoreticians for decades as a model system for investigating cell fate, cell signalling and tissue interactions. We are beginning to understand the mechanisms and signalling pathways that control and regulate the outgrowth and formation of the limb bud into a differentiated identifiable limb by late embryogenesis. However, the mechanisms underlying the development and maintenance of the vasculature of the developing limb are far from being completely understood. The vasculature supplies oxygen, nutrients and signals to developing tissues, allowing them to develop and grow. Moreover, a lot of evidence recently points to molecules involved in morphological development also controlling vascular development. Thus understanding how the vasculature forms and is patterned in the developing limb may further our understanding of limb development. In this review I outline how blood vessels are formed and maintained and how the developing chick limb is vascularized. I also review the role of the TGFbeta superfamily signalling pathway in the development of the chick limb vasculature: in particular, how antagonizing TGFbeta signalling in the developing chick limb has shed new light on the role vascular smooth muscle cells play in vessel calibre control and how this work has added to our understanding of TGFbeta superfamily signal transduction.
- Subjects :
- Cell signaling
Histology
Angiogenesis
Neovascularization, Physiologic
Reviews
Chick Embryo
Cell fate determination
Muscle, Smooth, Vascular
Smad7 Protein
Limb bud
Transforming Growth Factor beta
Animals
Limb development
Molecular Biology
Ecology, Evolution, Behavior and Systematics
biology
Extremities
Cell Biology
Transforming growth factor beta
Anatomy
Hedgehog signaling pathway
Cell biology
DNA-Binding Proteins
body regions
Vertebrates
Trans-Activators
biology.protein
Blood Vessels
Signal transduction
Signal Transduction
Developmental Biology
Subjects
Details
- ISSN :
- 14697580 and 00218782
- Volume :
- 202
- Database :
- OpenAIRE
- Journal :
- Journal of Anatomy
- Accession number :
- edsair.doi.dedup.....cc92c9361f9badd0b4a71307a0d70f19
- Full Text :
- https://doi.org/10.1046/j.1469-7580.2003.00133.x