Back to Search
Start Over
Sex reversal syndrome in the horse: Four new cases of feminization in individuals carrying a 64,XY SRY negative chromosomal complement
- Source :
- Animal Reproduction Science. 151:22-27
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Horses are characterized as having a greater rate of chromosomal abnormalities than other species, which are mainly related to the sex chromosome pair and produce a series of different anomalies known as disorders in sexual development (DSD). In the present study, three Pura Raza Española (PRE) and one Menorquín (MEN) horses were studied and an incompatibility in their genetic and phenotypic sex were detected. Animals were karyotyped by conventional and molecular cytogenetic analyses and characterized using genomic techniques. Although all individuals, were totally unrelated, these animals had the same abnormality (64,XY SRY negative DSD) despite having an anatomically normal external mare phenotype. Therefore, this syndrome could remain undiagnosed in a large percentage of cases because the physiological and morphological symptoms are rare. In the present study, a slight gonadal dysgenesis was observed only in older individuals. Interestingly this chromosomal abnormality has been previously reported less than twenty times, and never in the PRE or MEN horses. With the present research, it is demonstrated that the use of genetic and cytogenetic diagnostic tools in veterinary practice could be an important complementary test to determine the origin of unexplained reproductive failures among horses.
- Subjects :
- Male
Genetics
Phenotypic Sex
Feminization (biology)
Karyotype
Disorders of Sex Development
Horse
Gonadal dysgenesis
General Medicine
Sex reversal
Biology
medicine.disease
Phenotype
Endocrinology
Testis determining factor
Food Animals
medicine
Animals
Female
Horse Diseases
Animal Science and Zoology
Horses
Abnormality
Subjects
Details
- ISSN :
- 03784320
- Volume :
- 151
- Database :
- OpenAIRE
- Journal :
- Animal Reproduction Science
- Accession number :
- edsair.doi.dedup.....cc92e320f02c415d32f15c4cbf43cd1d