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Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids
- Source :
- Nature Biomedical Engineering
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group UK, 2020.
-
Abstract
- Strategies for selectively imaging and delivering drugs to tumours typically leverage differentially upregulated surface molecules on cancer cells. Here, we show that intravenously injected carbon quantum dots, functionalized with multiple paired α-carboxyl and amino groups that bind to the large neutral amino acid transporter 1 (which is expressed in most tumours), selectively accumulate in human tumour xenografts in mice and in an orthotopic mouse model of human glioma. The functionalized quantum dots, which structurally mimic large amino acids and can be loaded with aromatic drugs through π–π stacking interactions, enabled—in the absence of detectable toxicity—near-infrared fluorescence and photoacoustic imaging of the tumours and a reduction in tumour burden after the targeted delivery of chemotherapeutics to the tumours. The versatility of functionalization and high tumour selectivity of the quantum dots make them broadly suitable for tumour-specific imaging and drug delivery.<br />Intravenously injected functionalized carbon quantum dots that bind to the large neutral amino acid transporter 1 and that structurally mimic large amino acids selectively accumulate in human tumours in mice, facilitating targeted theranostics.
- Subjects :
- 0301 basic medicine
Medicine (miscellaneous)
Mice, Nude
Bioengineering
Large Neutral Amino Acid-Transporter 1
Theranostic Nanomedicine
Article
03 medical and health sciences
Mice
0302 clinical medicine
Drug Delivery Systems
Downregulation and upregulation
Cell Line, Tumor
Animals
Humans
Amino Acids
chemistry.chemical_classification
Mice, Inbred BALB C
Brain Neoplasms
Quantum dots
Fluorescence
Carbon
Computer Science Applications
Amino acid
030104 developmental biology
chemistry
Cell culture
Quantum dot
Drug delivery
Cancer cell
Biophysics
Female
Biomedical engineering
030217 neurology & neurosurgery
Biotechnology
Subjects
Details
- Language :
- English
- ISSN :
- 2157846X
- Database :
- OpenAIRE
- Journal :
- Nature Biomedical Engineering
- Accession number :
- edsair.doi.dedup.....cca55d75c00d8605c28f501bc3b25801