Back to Search
Start Over
A case of reversible cerebral vasoconstriction syndrome associated with anti-phospholipid antibody syndrome and systemic lupus erythematosus
- Source :
- eNeurologicalSci, Vol 24, Iss, Pp 100351-(2021), eNeurologicalSci
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- The pathomechanisms and treatment strategy for rare presentations of reversible cerebral vasoconstriction syndrome (RCVS) with anti-phospholipid syndrome (APS) remain to be determined. We report a 67-year-old woman with APS who presented with ischemic stroke due to RCVS. She was treated with low-dose cilostazol and lomerizine hydrochloride, which resulted in functional improvement and recovery of vasoconstriction within 12 weeks. Her plasma endothelin-1 level was decreased after relief of vasoconstriction, compared with the pre-treatment condition. Increased plasma endothelin-1 may be related to the underlying pathomechanism of RCVS with APS, against which cilostazol and lomerizine hydrochloride could be effective.<br />Highlights • We described a case of reversible cerebral vasoconstriction syndrome (RCVS) with anti-phospholipid syndrome (APS). • Treatment with low-dose cilostazol and lomerizine hydrochloride could therapeutic for RCVS with APS. • These treatments may alleviate the endothelin-1-related cerebral vascular dysfunction in RCVS/APS.
- Subjects :
- medicine.medical_specialty
Case Report
Anti-Phospholipid Antibody Syndrome
03 medical and health sciences
0302 clinical medicine
Lomerizine
Internal medicine
medicine
030212 general & internal medicine
RC346-429
Endothelin-1
business.industry
Anti-phospholipid antibody syndrome
medicine.disease
Endothelin 1
Reversible cerebral vasoconstriction syndrome
Cilostazol
Neurology
Ischemic stroke
Cardiology
Treatment strategy
Neurology. Diseases of the nervous system
medicine.symptom
business
030217 neurology & neurosurgery
Vasoconstriction
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 24056502
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- eNeurologicalSci
- Accession number :
- edsair.doi.dedup.....ccac8746daa76d24876a7e03b833ce3f