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Effects of ventral intermediate nucleus deep brain stimulation across multiple effectors in essential tremor
- Source :
- Clin Neurophysiol
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Objective Essential tremor (ET) prominently affects the upper-limbs during voluntary movements, but can also affect the lower-limbs, head, and chin. Although deep brain stimulation (DBS) of the ventral intermediate nucleus (VIM) of thalamus improves both clinical ratings and quantitative measures of tremor, no study has quantified effects of DBS on tremor across multiple body parts. Our objective was to quantify therapeutic effects of DBS across multiple body parts in ET. Methods We performed quantitative assessment of tremor in ET patients who had DBS for at least one year. We assessed tremor on and off VIM-stimulation using triaxial accelerometers on the upper-limbs, lower-limbs, head and chin during seated and standing tasks. Results VIM-DBS significantly reduced tremor, but there was no statistical difference in degree of tremor reduction across the measured effectors. Compared to healthy controls, ET patients treated with DBS showed significantly greater tremor power (4–8 Hz) across all effectors during seated and standing tasks. Conclusions VIM-DBS reduced tremor in ET patients. There was no significant difference in the degree of tremor reduction across the measured effectors. Significance This study provides new quantitative evidence that VIM-DBS is effective at reducing tremor across multiple parts of the body.
- Subjects :
- Male
Chin
medicine.medical_specialty
Deep brain stimulation
Deep Brain Stimulation
Essential Tremor
medicine.medical_treatment
Acceleration
Thalamus
Article
050105 experimental psychology
03 medical and health sciences
0302 clinical medicine
Physical medicine and rehabilitation
Physiology (medical)
Accelerometry
Quantitative assessment
Humans
Medicine
0501 psychology and cognitive sciences
Aged
Aged, 80 and over
Leg
Sitting Position
Ventral Thalamic Nuclei
Ventral intermediate nucleus
Essential tremor
business.industry
05 social sciences
Significant difference
Middle Aged
Hand
medicine.disease
Sensory Systems
nervous system diseases
medicine.anatomical_structure
Neurology
Case-Control Studies
Standing Position
Female
Neurology (clinical)
In degree
business
Head
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 13882457
- Volume :
- 131
- Database :
- OpenAIRE
- Journal :
- Clinical Neurophysiology
- Accession number :
- edsair.doi.dedup.....ccb6d68f221f749652f721a8d2d661f3