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Impact of platelet reactivity to adenosine diphosphate before implantation of drug-eluting stents on subsequent adverse cardiac events in patients with stable angina

Authors :
Masaya Otsuka
Mamoru Toyofuku
Yasuki Kihara
Hironori Ueda
Tomoharu Kawase
Hiromichi Tamekiyo
Tomokazu Okimoto
Yasuhiko Hayashi
Chikaaki Motoda
Source :
Circulation journal : official journal of the Japanese Circulation Society. 76(3)
Publication Year :
2012

Abstract

Background: Diverse pharmacological effects of anti-platelet thienopyridines due to individual differences in metabolism have been reported. However, an association between on-treatment platelet reactivity and adverse ischemic events after drug-eluting stent (DES) implantation in Japanese patients has not been fully elucidated. Methods and Results: A total of 450 consecutive patients on dual anti-platelet therapy (aspirin and ticlopidine) with stable angina who underwent DES implantation were enrolled. Adenosine diphosphate (ADP)-induced platelet aggregation was measured before DES implantation using the screen filtration pressure method. The ADP concentration necessary for 50% aggregation was designated as the platelet aggregation threshold index (PATI). A composite primary endpoint of cardiac death, myocardial infarction, target lesion revascularization (TLR), and stent thrombosis occurring within 1 year after stenting, was evaluated. A PATI value

Details

ISSN :
13474820
Volume :
76
Issue :
3
Database :
OpenAIRE
Journal :
Circulation journal : official journal of the Japanese Circulation Society
Accession number :
edsair.doi.dedup.....ccb9bdf654a1b4aa076d8309e5fdb8b9