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Impact of platelet reactivity to adenosine diphosphate before implantation of drug-eluting stents on subsequent adverse cardiac events in patients with stable angina
- Source :
- Circulation journal : official journal of the Japanese Circulation Society. 76(3)
- Publication Year :
- 2012
-
Abstract
- Background: Diverse pharmacological effects of anti-platelet thienopyridines due to individual differences in metabolism have been reported. However, an association between on-treatment platelet reactivity and adverse ischemic events after drug-eluting stent (DES) implantation in Japanese patients has not been fully elucidated. Methods and Results: A total of 450 consecutive patients on dual anti-platelet therapy (aspirin and ticlopidine) with stable angina who underwent DES implantation were enrolled. Adenosine diphosphate (ADP)-induced platelet aggregation was measured before DES implantation using the screen filtration pressure method. The ADP concentration necessary for 50% aggregation was designated as the platelet aggregation threshold index (PATI). A composite primary endpoint of cardiac death, myocardial infarction, target lesion revascularization (TLR), and stent thrombosis occurring within 1 year after stenting, was evaluated. A PATI value
- Subjects :
- Male
medicine.medical_specialty
Ticlopidine
Platelet Aggregation
medicine.medical_treatment
Myocardial Ischemia
Revascularization
Percutaneous coronary intervention
chemistry.chemical_compound
Internal medicine
medicine
Humans
Platelet
Myocardial infarction
Angina, Stable
Aged
Aged, 80 and over
Aspirin
business.industry
Stent
Anti-platelet therapy
Drug-Eluting Stents
General Medicine
Middle Aged
medicine.disease
Adenosine Diphosphate
Adenosine diphosphate
chemistry
Platelet reactivity to ADP
Drug-eluting stent
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Platelet Aggregation Inhibitors
medicine.drug
Subjects
Details
- ISSN :
- 13474820
- Volume :
- 76
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Circulation journal : official journal of the Japanese Circulation Society
- Accession number :
- edsair.doi.dedup.....ccb9bdf654a1b4aa076d8309e5fdb8b9