Fetal Autoimmune-Mediated Complete Heart Block: Favorable Mortality Outcome In 20 Cases From A Single Center

Background: Fetuses exposed to maternal autoimmune diseases, such as Lupus or Sjogren's syndrome, are at risk of developing autoimmune-mediated heart block. Maternal anti-Ro/SSA or anti-La/SSB antibodies produced cross the human placenta and cause inflammation, cell death, and scaring of the fetal cardiac conduction system. The risk of mortality to the exposed fetus has been reported to be at least 18%. We were interested in detailing the outcomes and associated prenatal …