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No major effect of the insulin-like growth factor I gene on bone mineral density in premenopausal Chinese women
- Source :
- Bone. 36(4)
- Publication Year :
- 2004
-
Abstract
- Osteoporosis is a major public health problem, mainly characterized by low bone mineral density (BMD). BMD is a complex trait that is determined by multiple genes. Insulin-like growth factor I (IGF-I) is an important growth factor of bone and thus IGF-I gene has been considered as an attractive candidate gene for osteoporosis. A few studies on the relationship between variants of the IGF-I gene and BMD variation, via traditional association and/or linkage methods, have yielded conflicting results. In this study, we simultaneously tested association and/or linkage of a cytosine-adenine (CA) repeat polymorphism at 1 kb upstream of the transcription initiation site of the IGF-I gene with BMD variation in a large cohort of premenopausal Chinese women. A total of 1263 subjects from 402 Chinese nuclear families were examined. Each family consists of both parents and at least one daughter aged between 20 and 45 years. BMDs (g/cm 2 ) at the lumbar spine and hip were measured using dual-energy X-ray absorptiometry (DXA). Applying the QTDT (quantitative transmission disequilibrium tests) progam, we did not find significant evidence of association or linkage between the CA repeat polymorphism of the IGF-I gene and BMD variation at any skeletal site. Our data do not support the IGF-I gene having major effect on BMD variation in premenopausal Chinese women.
- Subjects :
- musculoskeletal diseases
medicine.medical_specialty
Candidate gene
China
Histology
Physiology
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
media_common.quotation_subject
Osteoporosis
Biology
Insulin-like growth factor
Genetic linkage
Polymorphism (computer science)
Bone Density
Internal medicine
medicine
Humans
Insulin-Like Growth Factor I
Nuclear family
Alleles
media_common
Bone mineral
Daughter
Middle Aged
medicine.disease
Endocrinology
Premenopause
Female
Subjects
Details
- ISSN :
- 87563282
- Volume :
- 36
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Bone
- Accession number :
- edsair.doi.dedup.....ccd6165fbed98ea8b5ca751c9839b947