Back to Search
Start Over
CD8+ regulatory T cells generated by neonatal recognition of peripheral self-antigen
- Source :
- Proceedings of the National Academy of Sciences of the United States of America. 103(41)
- Publication Year :
- 2006
-
Abstract
- In comparison with CD4 + regulatory T cells, the generation and function of immunomodulatory CD8 + T cells is less well defined. Here we describe the existence of regulatory anti-K b -specific CD8 + T cells that are rendered tolerant during neonatal life via antigen contact exclusively on keratinocytes. These regulatory T cells maintain tolerance during adulthood as they prevent K b -specific graft rejection by naïve CD8 + T cells. Third-party immune responses remain unaffected. Up-regulation of TGF-β1 and granzyme B in the regulatory CD8 + T cell population suggests the involvement of these molecules in common suppressive pathways shared with CD4 + regulatory T cells. In summary, CD8 + regulatory T cells can be induced extrathymically through antigen contact on neonatally accessible parenchymal cells and maintain tolerance throughout adult life.
- Subjects :
- T cell
Mice, Transgenic
CD8-Positive T-Lymphocytes
Lymphocyte Activation
Autoantigens
T-Lymphocytes, Regulatory
Interleukin 21
Mice
Cell Line, Tumor
medicine
Immune Tolerance
Cytotoxic T cell
Animals
IL-2 receptor
Antigen-presenting cell
Mice, Knockout
Multidisciplinary
CD40
biology
CD28
Cell Differentiation
Biological Sciences
Natural killer T cell
medicine.anatomical_structure
Animals, Newborn
Immunology
biology.protein
Subjects
Details
- ISSN :
- 00278424
- Volume :
- 103
- Issue :
- 41
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Accession number :
- edsair.doi.dedup.....cce8bbda94b8e56e81c1a10f6e1ab426