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Influence of Comorbidities and Medication Use on Tilt Table Test Outcome in Elderly Patients
- Source :
- Pacing and Clinical Electrophysiology. 30:540-543
- Publication Year :
- 2007
- Publisher :
- Wiley, 2007.
-
Abstract
- Background: The tilt table test (TTT) is a useful diagnostic tool in people with unexplained syncope, dizziness, and falls. However, preexisting comorbidities and medications affecting hemodynamic response might affect TTT outcome (i.e. presence or absence of vasomotor syncope). We studied the influence of these compounding factors on TTT outcome. Methods: One hundred and sixty-four elderly patients with a mean (±SD) age of 80.0 ± 6.1 years (M:F 104:60) underwent TTT. Heart rate and blood pressure were recorded continuously using a noninvasive device (Task Force Monitorâ„¢, CNS systems, Graz, Austria). Predictors of TTT outcome in a backward regression analysis included age, gender, comorbidities (chronic heart failure, hypertension, diabetes, and cerebrovascular disease), and drugs (β-blockers, angiotensin-converting enzyme inhibitors, calcium channel blockers, diuretics, digoxin, opioids, antidepressants, and nonsteroidal antiinflammatory agents). Results: TTT was positive in 30 patients (18.3%). None of the above factors were a significant predictor of TTT outcome. The use of calcium channel blockers predicted a drop in systolic blood pressure after 2 minutes of TTT (P = 0.048, R2= 0.018). However, this was not associated with significant changes in heart rate and did not influence TTT outcome. Conclusion: The TTT outcome was not influenced by comorbidities or medications. TTT is a reliable diagnostic tool in a population characterized by significant comorbidities and polypharmacy.
- Subjects :
- Male
medicine.medical_specialty
Digoxin
education
Population
Comorbidity
Syncope
Tilt table test
Drug Therapy
Heart Rate
Tilt-Table Test
Internal medicine
Heart rate
medicine
Humans
Aged
Aged, 80 and over
Polypharmacy
education.field_of_study
medicine.diagnostic_test
business.industry
Blood Pressure Determination
General Medicine
medicine.disease
Surgery
Blood pressure
Heart failure
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
medicine.drug
Subjects
Details
- ISSN :
- 15408159 and 01478389
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Pacing and Clinical Electrophysiology
- Accession number :
- edsair.doi.dedup.....cd0e47fdca8c9f3773ba0454061712ba
- Full Text :
- https://doi.org/10.1111/j.1540-8159.2007.00705.x